Exaggerated blood pressure response to exercise is associated with subclinical vascular impairment in healthy normotensive individuals.
Exercise
arterial stiffness
mean arterial pressure
urinary albumin excretion
vascular impairment
Journal
Clinical and experimental hypertension (New York, N.Y. : 1993)
ISSN: 1525-6006
Titre abrégé: Clin Exp Hypertens
Pays: England
ID NLM: 9305929
Informations de publication
Date de publication:
02 Jan 2021
02 Jan 2021
Historique:
pubmed:
18
8
2020
medline:
5
5
2021
entrez:
18
8
2020
Statut:
ppublish
Résumé
This study was designed to evaluate the possible association between an exaggerated blood pressure (BP) response to exercise and subclinical vascular impairment in normotensive individuals. The study participants consisted of 92 untreated normotensive men (aged 42 ± 9 years) without a history of cardiovascular disease or stroke. A graded exercise test was conducted using a bicycle ergometer, and the mean arterial pressure (MAP) during submaximal exercise was evaluated. The brachial-ankle pulse wave velocity (baPWV) was measured as an index of arterial stiffness. The second peak of radial systolic BP (SBP2) was used as an estimate of central BP. The albumin-to-creatinine ratio (ACR) values were determined as the mean of two nonconsecutive spot urine specimens. Compared with individuals with a normal response (MAP z-score < +1.0, These results suggest that subclinical vascular impairment is associated with an exaggerated increase in BP during exercise even in the absence of clinical hypertension.
Sections du résumé
BACKGROUND
BACKGROUND
This study was designed to evaluate the possible association between an exaggerated blood pressure (BP) response to exercise and subclinical vascular impairment in normotensive individuals.
METHODS
METHODS
The study participants consisted of 92 untreated normotensive men (aged 42 ± 9 years) without a history of cardiovascular disease or stroke. A graded exercise test was conducted using a bicycle ergometer, and the mean arterial pressure (MAP) during submaximal exercise was evaluated. The brachial-ankle pulse wave velocity (baPWV) was measured as an index of arterial stiffness. The second peak of radial systolic BP (SBP2) was used as an estimate of central BP. The albumin-to-creatinine ratio (ACR) values were determined as the mean of two nonconsecutive spot urine specimens.
RESULTS
RESULTS
Compared with individuals with a normal response (MAP z-score < +1.0,
CONCLUSIONS
CONCLUSIONS
These results suggest that subclinical vascular impairment is associated with an exaggerated increase in BP during exercise even in the absence of clinical hypertension.
Identifiants
pubmed: 32799691
doi: 10.1080/10641963.2020.1806292
doi:
Substances chimiques
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM