The Distributed Nociceptive System: A Framework for Understanding Pain.

Computer Communication Networks Humans Neurons Nociception Pain
bilateral biomarkers nociception pain population coding recruitment

Journal

Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616

Informations de publication

Date de publication:
10 2020
Historique:
received: 14 04 2020
revised: 30 06 2020
accepted: 12 07 2020
pubmed: 18 8 2020
medline: 31 7 2021
entrez: 18 8 2020
Statut: ppublish

Résumé

Chronic pain remains challenging to both diagnose and treat. These challenges, in part, arise from limited systems-level understanding of the basic mechanisms that process nociceptive information and ultimately instantiate a subjectively available experience of pain. Here, I provide a framework, the distributed nociceptive system, for understanding nociceptive mechanisms at a systems level by integrating the concepts of neural population coding with distributed processing. Within this framework, wide-spread engagement of populations of neurons produces representations of nociceptive information that are highly resilient to disruption. The distributed nociceptive system provides a foundation for understanding complex spatial aspects of chronic pain and provides an impetus for nonpharmacological cognitive and physical therapies that can effectively target the highly distributed system that gives rise to an experience of pain.

Identifiants

DOI: 10.1016/j.tins.2020.07.004 PMID: 32800534 PMC: PMC7530033
pubmed: 32800534
pii: S0166-2236(20)30168-5
doi: 10.1016/j.tins.2020.07.004
pmc: PMC7530033
mid: NIHMS1613332
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

780-794

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR074795
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT010171
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS085391
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS101321
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Robert C Coghill (RC)

Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital, OH, USA; Department of Pediatrics, University of Cincinnati, OH, USA; Center for Understanding Pediatric Pain, Cincinnati Children's Hospital, OH, USA. Electronic address: Robert.Coghill@cchmc.org.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Systèmes informatiques › Réseaux de communication entre ordinateurs › The Distributed Nociceptive System: A...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Distributed Nociceptive System: A...
questionsmedicales.fr › Cellules › Neurones › The Distributed Nociceptive System: A...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Perception de la douleur › Nociception › The Distributed Nociceptive System: A...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › The Distributed Nociceptive System: A...