A Senescence-Centric View of Aging: Implications for Longevity and Disease.
SASP,
aging
cellular senescence
senescence hallmarks
senotherapeutics
Journal
Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
13
05
2020
revised:
03
07
2020
accepted:
10
07
2020
pubmed:
18
8
2020
medline:
25
6
2021
entrez:
18
8
2020
Statut:
ppublish
Résumé
Cellular senescence is a state of stable cell cycle arrest associated with macromolecular alterations and secretion of proinflammatory cytokines and molecules. From their initial discovery in the 1960s, senescent cells have been hypothesized as potential contributors to the age-associated loss of regenerative potential. Here, we discuss recent evidence that implicates cellular senescence as a central regulatory mechanism of the aging process. We provide a comprehensive overview of age-associated pathologies in which cellular senescence has been implicated. We describe mechanisms by which senescent cells drive aging and diseases, and we discuss updates on exploiting these mechanisms as therapeutic targets. Finally, we critically analyze the use of senotherapeutics and their translation to the clinic, highlighting limitations and suggesting ideas for future applications and developments.
Identifiants
pubmed: 32800659
pii: S0962-8924(20)30143-4
doi: 10.1016/j.tcb.2020.07.002
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
777-791Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.