Mechanisms of Long Noncoding RNA Nuclear Retention.

Animals Cell Nucleus / genetics Chromatin / genetics Humans RNA, Long Noncoding / genetics
RNA processing cis-motifs conservation export lncRNA nuclear localization trans-factors

Journal

Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674

Informations de publication

Date de publication:
11 2020
Historique:
received: 05 05 2020
revised: 27 06 2020
accepted: 15 07 2020
pubmed: 18 8 2020
medline: 25 6 2021
entrez: 18 8 2020
Statut: ppublish

Résumé

Long noncoding RNAs (lncRNAs) are crucial regulators in diverse cellular contexts and biological processes. The subcellular localization of lncRNAs determines their modes of action. Compared to mRNAs, however, many mRNA-like lncRNAs are preferentially localized to the nucleus where they regulate chromatin organization, transcription, and different nuclear condensates. Recent studies have revealed the complex mechanisms that govern lncRNA nuclear retention. We review current understanding of how the transcription and processing of lncRNAs, motifs within lncRNAs, and trans-factors coordinately contribute to their nuclear retention in mammalian cells.

Identifiants

DOI: 10.1016/j.tibs.2020.07.001 PMID: 32800670
pubmed: 32800670
pii: S0968-0004(20)30174-2
doi: 10.1016/j.tibs.2020.07.001
pii:
doi:

Substances chimiques

Chromatin 0
RNA, Long Noncoding 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

947-960

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Chun-Jie Guo (CJ)

State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of the Chinese Academy of Sciences, CAS, Shanghai 200031, China.

Guang Xu (G)

State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of the Chinese Academy of Sciences, CAS, Shanghai 200031, China.

Ling-Ling Chen (LL)

State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of the Chinese Academy of Sciences, CAS, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China. Electronic address: linglingchen@sibcb.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mechanisms of Long Noncoding RNA Nuclear Retention.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Mechanisms of Long Noncoding RNA Nuclear Retention.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Mechanisms of Long Noncoding RNA Nuclear Retention.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mechanisms of Long Noncoding RNA Nuclear Retention.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › Mechanisms of Long Noncoding RNA Nuclear Retention.