Prolonged hypoxia delays aging and preserves functionality of human amniotic fluid stem cells.

Amniotic Fluid / cytology Cell Hypoxia Cellular Senescence Humans Stem Cells / cytology
Aging Amniotic fluid stem cells Cellular senescence Hypoxia Mesenchymal stem cells Oxygen Senescence pluripotency Stem cells

Journal

Mechanisms of ageing and development
ISSN: 1872-6216
Titre abrégé: Mech Ageing Dev
Pays: Ireland
ID NLM: 0347227

Informations de publication

Date de publication:
10 2020
Historique:
received: 10 04 2020
revised: 07 08 2020
accepted: 09 08 2020
pubmed: 18 8 2020
medline: 14 10 2021
entrez: 18 8 2020
Statut: ppublish

Résumé

Human amniotic fluid stem cells (hAFSCs) are an emerging tool in regenerative medicine because they have the ability to differentiate into various lineages and efficiently improve tissue regeneration with no risk of tumorigenesis. Although hAFSCs are easily isolated from the amniotic fluid, their expansion ex vivo is limited by a quick exhaustion which impairs replicative potential and differentiation capacity. In this study, we evaluate various aging features of hAFSCs cultured at different oxygen concentrations. We show that low oxygen (1% O

Identifiants

DOI: 10.1016/j.mad.2020.111328 PMID: 32800796
pubmed: 32800796
pii: S0047-6374(20)30124-X
doi: 10.1016/j.mad.2020.111328
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111328

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Francesca Casciaro (F)

University of Groningen, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center, Groningen (UMCG), The Netherlands; Department of Surgical, Medical, Dental and Morphological Sciences With Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Italy; Cellular Signalling Laboratory Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. Electronic address: francesca.casciaro3@unibo.it.

Michela Borghesan (M)

University of Groningen, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center, Groningen (UMCG), The Netherlands. Electronic address: m.borghesan@umcg.nl.

Francesca Beretti (F)

Department of Surgical, Medical, Dental and Morphological Sciences With Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Italy. Electronic address: francesca.beretti@unimore.it.

Manuela Zavatti (M)

Department of Surgical, Medical, Dental and Morphological Sciences With Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Italy. Electronic address: manuela.zavatti@unimore.it.

Emma Bertucci (E)

Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Modena, Italy. Electronic address: emma.bertucci@unimore.it.

Matilde Yung Follo (MY)

Cellular Signalling Laboratory Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. Electronic address: matilde.follo@unibo.it.

Tullia Maraldi (T)

Department of Surgical, Medical, Dental and Morphological Sciences With Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Italy. Electronic address: tullia.maraldi@unimore.it.

Marco Demaria (M)

University of Groningen, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center, Groningen (UMCG), The Netherlands. Electronic address: PhDm.demaria@umcg.nl.

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Classifications MeSH

questionsmedicales.fr › Structures de l'embryon › Foetus › Liquide amniotique › Prolonged hypoxia delays aging and preserves...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Respiration cellulaire › Hypoxie cellulaire › Prolonged hypoxia delays aging and preserves...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Prolonged hypoxia delays aging and preserves...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prolonged hypoxia delays aging and preserves...
questionsmedicales.fr › Cellules › Cellules souches › Prolonged hypoxia delays aging and preserves...