IgA Vasculitis With Underlying Liver Cirrhosis: A French Nationwide Case Series of 20 Patients.

Adult Aged Female Humans IgA Vasculitis Immunoglobulin A Liver Cirrhosis / complications Middle Aged Retrospective Studies Vasculitis
Henoch-Schönlein purpura IgA vasculitis alcohol cirrhosis liver

Journal

The Journal of rheumatology
ISSN: 0315-162X
Titre abrégé: J Rheumatol
Pays: Canada
ID NLM: 7501984

Informations de publication

Date de publication:
05 2021
Historique:
accepted: 06 08 2020
pubmed: 18 8 2020
medline: 28 9 2021
entrez: 18 8 2020
Statut: ppublish

Résumé

Immunoglobulin A vasculitis (IgAV) and nephropathy (IgAN) share common immunological mechanisms. Liver cirrhosis is well known to be associated with IgAN. Here, we aimed to describe the presentation and outcome of IgAV patients with underlying cirrhosis. We conducted a French nationwide retrospective study of adult patients presenting with both IgAV and cirrhosis. Baseline characteristics were compared to those of the 260 patients included in the French nationwide IgAV registry (IGAVAS). Twenty patients were included, and 7 (35%) were female. The mean ± SD age was 62.7 ± 11 years. At baseline, compared with IGAVAS patients, patients with underlying cirrhosis were older (62.7 ± 11 vs 50.1 ± 18, We report the first case series of IgAV patients with underlining cirrhosis, to our knowledge, which was mainly alcohol related. The liver disease did not seem to affect baseline vasculitis characteristics. Physicians should investigate the existence of liver cirrhosis at IgAV diagnosis, especially in the context of alcohol abuse.

Identifiants

DOI: 10.3899/jrheum.200293 PMID: 32801133
pubmed: 32801133
pii: jrheum.200293
doi: 10.3899/jrheum.200293
doi:

Substances chimiques

Immunoglobulin A 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

735-740

Informations de copyright

Copyright © 2021 by the Journal of Rheumatology.

Auteurs

Ines Elhani (I)

I. Elhani, MD, A. Hankard, MD, H. de Boysson, MD, A. Aouba, MD, Department of Internal Medicine, Caen, Normandie Université, UNICAEN, CHU de Caen Normandie.
ORCID: 0000-0002-9767-2262

Evangéline Pillebout (E)

E. Pillebout, MD, Department of Nephrology, Hôpital Saint Louis, AP-HP, Paris.

Benjamin Terrier (B)

B. Terrier, MD, Université Paris Descartes, and Department of Internal Medicine, Hôpital Cochin, and National Referral Center for Systemic and Autoimmune Diseases, Hôpital Cochin, Paris.

Antoine Hankard (A)

I. Elhani, MD, A. Hankard, MD, H. de Boysson, MD, A. Aouba, MD, Department of Internal Medicine, Caen, Normandie Université, UNICAEN, CHU de Caen Normandie.
ORCID: 0000-0003-2305-7117

François Vrtovsnik (F)

F. Vrtovsnik, MD, Department of Nephrology, Bichat-Claude Bernard Hospital, AP-HP, and Inserm U1149 - CRI, University of Paris, Paris.

Noémie Jourde-Chiche (N)

N. Jourde-Chiche, MD, S. Greillier, MD, Aix-Marseille Univ, C2VN, INSERM, INRA, Centre de Néphrologie et Transplantation Rénale, CHU de la Conception, AP-HM, Marseille.
ORCID: 0000-0001-9315-1577

Sophie Greillier (S)

N. Jourde-Chiche, MD, S. Greillier, MD, Aix-Marseille Univ, C2VN, INSERM, INRA, Centre de Néphrologie et Transplantation Rénale, CHU de la Conception, AP-HM, Marseille.

Matthieu Groh (M)

M. Groh, MD, Department of Internal Medicine, National Referral Center for Hypereosinophilic Syndrome (CEREO), Suresnes.

Nabil Belfeki (N)

N. Belfeki, MD, Department of Internal Medicine, Groupe Hospitalier Sud Ile de France, Melun.

Adrien Bigot (A)

A. Bigot, MD, F. Maillot, MD, A. Audemard-Verger, MD, PhD, Department of Internal Medicine and Clinical Immunology, CHRU Tours, and University of Tours, Tours.

Hubert de Boysson (H)

I. Elhani, MD, A. Hankard, MD, H. de Boysson, MD, A. Aouba, MD, Department of Internal Medicine, Caen, Normandie Université, UNICAEN, CHU de Caen Normandie.

Georges-Philippe Pageaux (GP)

G.P. Pageaux, MD, Liver Transplantation Unit, Digestive Department, Saint Eloi University Hospital, University of Montpellier, Montpellier.

Loïc Raffray (L)

L. Raffray, MD, Department of Internal Medicine, Centre Hospitalier Universitaire de la Réunion, Réunion.

Geoffrey Urbanski (G)

G. Urbanski, MD, Department of Internal Medicine, Centre Hospitalier Universitaire d'Angers, Angers.

Isabelle Ollivier (I)

I. Ollivier, MD, Department of Hepato-Gastroenterology and Nutrition, Caen University Hospital, Caen, France.

Francois Maillot (F)

A. Bigot, MD, F. Maillot, MD, A. Audemard-Verger, MD, PhD, Department of Internal Medicine and Clinical Immunology, CHRU Tours, and University of Tours, Tours.

Achille Aouba (A)

I. Elhani, MD, A. Hankard, MD, H. de Boysson, MD, A. Aouba, MD, Department of Internal Medicine, Caen, Normandie Université, UNICAEN, CHU de Caen Normandie.

Alexandra Audemard-Verger (A)

A. Bigot, MD, F. Maillot, MD, A. Audemard-Verger, MD, PhD, Department of Internal Medicine and Clinical Immunology, CHRU Tours, and University of Tours, Tours; a.audemard-verger@chu-tours.fr.
ORCID: 0000-0002-0226-5016

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › IgA Vasculitis With Underlying Liver...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › IgA Vasculitis With Underlying Liver...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › IgA Vasculitis With Underlying Liver...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations cutanées › Purpura › Purpura de Schönlein-Henoch › IgA Vasculitis With Underlying Liver...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline A › IgA Vasculitis With Underlying Liver...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Cirrhose du foie › IgA Vasculitis With Underlying Liver...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › IgA Vasculitis With Underlying Liver...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › IgA Vasculitis With Underlying Liver...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Vascularite › IgA Vasculitis With Underlying Liver...