Quantitative CT Analysis in Patients with Pulmonary Emphysema: Do Calculated Differences Between Full Inspiration and Expiration Correlate with Lung Function?
chronic obstructive pulmonary disease
pulmonary emphysema
pulmonary function test
quantitative CT
Journal
International journal of chronic obstructive pulmonary disease
ISSN: 1178-2005
Titre abrégé: Int J Chron Obstruct Pulmon Dis
Pays: New Zealand
ID NLM: 101273481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
03
2020
accepted:
02
07
2020
entrez:
18
8
2020
pubmed:
18
8
2020
medline:
29
6
2021
Statut:
epublish
Résumé
The aim of this retrospective study was to evaluate correlations between parameters of quantitative computed tomography (QCT) analysis, especially the 15th percentile of lung attenuation (P15), and parameters of clinical tests in a large group of patients with pulmonary emphysema. One hundred and seventy-two patients with pulmonary emphysema and chronic obstructive pulmonary disease (COPD) global initiative for chronic obstructive lung disease (GOLD) stage 3 or 4 were assessed by nonenhanced thin-section CT scans in full inspiratory and expiratory breath-hold, pulmonary function test (PFT), a 6-minute walk test (6MWT), and quality of life questionnaires (SGRQ and CAT). QCT parameters included total lung volume (TLV), total emphysema score (TES), and P15, all measured at inspiration (IN) and expiration (EX). Differences between inspiration and expiration were calculated for TLV (TLV CT-measured lung volume in inspiration (TLV Our results suggest that QCT can help predict the severity of lung function decrease in patients with pulmonary emphysema and COPD GOLD 3 or 4. Some QCT parameters, including P15
Identifiants
pubmed: 32801683
doi: 10.2147/COPD.S253602
pii: 253602
pmc: PMC7413697
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1877-1886Informations de copyright
© 2020 Song et al.
Déclaration de conflit d'intérêts
Author Bianca C Lassen-Schmidt is an employee of Fraunhofer MEVIS, the developer of the MeVis PULMO3D software. Ralf H Hubner reports personal fees from Pulmonx during the conduct of the study. All other authors report no conflicts of interest in this work.
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