New-Onset Uveitis Possibly Caused by Secukinumab in a 47-Year-Old Male Patient with Long-Standing Ankylosing Spondylitis.
IL-17A inhibitors
ankylosing spondylitis
biologics
iritis
secukinumab
spondyloarthritis
uveitis
Journal
International medical case reports journal
ISSN: 1179-142X
Titre abrégé: Int Med Case Rep J
Pays: New Zealand
ID NLM: 101566269
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
06
2020
accepted:
24
07
2020
entrez:
18
8
2020
pubmed:
18
8
2020
medline:
18
8
2020
Statut:
epublish
Résumé
Secukinumab, "an IL-17 antagonist", is one of the biological agents used to treat active ankylosing spondylitis (AS). Although it has been proven that certain agents are linked with a paradoxical increase in uveitis, there are limited data on whether secukinumab has this effect or not. We report a case of a new-onset anterior uveitis after 6 months of starting secukinumab in a 47-year-old male, HLA-B27 positive AS patient. He had a long-standing history with the disease over 25 years. He was treated in the past with methotrexate then adalimumab and later on with etanercept. He had no history of uveitis during all of this time. The uveitis was mild and treated conventionally with local measures while secukinumab was maintained. After a close follow-up, the uveitis had completely resolved. Is this part of the original disease or a possible side effect from secukinumab?
Identifiants
pubmed: 32801946
doi: 10.2147/IMCRJ.S265812
pii: 265812
pmc: PMC7415454
doi:
Types de publication
Case Reports
Langues
eng
Pagination
331-334Informations de copyright
© 2020 Nadwi et al.
Déclaration de conflit d'intérêts
Hani Almoallim reports this work was supervised and funded by Alzaidi Chair of Research in Rheumatic, Umm Alqura University, Makkah, Saudi Arabia. The authors report no other potential conflicts of interest for this work.
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