Effect of Electroacupuncture versus Sham Electroacupuncture in Patients with Knee Osteoarthritis: A Pilot Randomized Controlled Trial.
Journal
Evidence-based complementary and alternative medicine : eCAM
ISSN: 1741-427X
Titre abrégé: Evid Based Complement Alternat Med
Pays: United States
ID NLM: 101215021
Informations de publication
Date de publication:
2020
2020
Historique:
received:
19
05
2020
revised:
22
06
2020
accepted:
08
07
2020
entrez:
18
8
2020
pubmed:
18
8
2020
medline:
18
8
2020
Statut:
epublish
Résumé
To explore the feasibility of evaluating the effectiveness and safety of electroacupuncture versus sham electroacupuncture for patients with knee osteoarthritis (KOA). A pilot randomized controlled trial was conducted at a teaching hospital in Beijing. A total of 30 patients with KOA (Kellgren grade II or III) were randomly allocated to an eight-week treatment of either electroacupuncture or sham electroacupuncture. Patients and outcome assessors were blinded to group allocation. The primary outcome was the proportion of responders achieving at least 1.14 seconds decrease in the Timed Up and Go Test (TUG) at week eight compared with baseline. The secondary outcomes included the knee range of motion, the knee extensor and flexor muscle strength, Lequesne index, 9-step stair-climb test (9-SCT), and TUG. Of 30 patients allocated to two groups, 27 (90%) completed the study. The proportion of responders was 53.3% (8 of 15) for electroacupuncture group and 26.7% (4 of 15) for sham electroacupuncture group by the intention-to-treat analysis ( Our research demonstrated that further evaluation of the effectiveness of electroacupuncture versus sham electroacupuncture was feasible and safe for patients with KOA. Whether or not the electroacupuncture can improve the physical functions of knee joint, expand the knee range of motion, and increase the extensor and flexor muscle strength more significantly than sham electroacupuncture, future studies can be designed with larger sample size, randomization design and less biases. This trial is registered with NCT03366363.
Identifiants
pubmed: 32802114
doi: 10.1155/2020/1686952
pmc: PMC7414333
doi:
Banques de données
ClinicalTrials.gov
['NCT03366363']
Types de publication
Journal Article
Langues
eng
Pagination
1686952Informations de copyright
Copyright © 2020 Qi Wang et al.
Déclaration de conflit d'intérêts
The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
Biomed Pharmacother. 2020 Mar;123:109724
pubmed: 31918209
Osteoarthritis Cartilage. 2013 Aug;21(8):1042-52
pubmed: 23680877
Chin Med J (Engl). 2010 Jan 20;123(2):165-72
pubmed: 20137365
Arthritis Res Ther. 2019 May 14;21(1):120
pubmed: 31088511
Osteoarthritis Cartilage. 2010 Jan;18(1):24-33
pubmed: 19751691
Nat Rev Rheumatol. 2016 Feb;12(2):92-101
pubmed: 26439406
Am J Phys Med Rehabil. 2001 Jan;80(1):13-8
pubmed: 11138949
Pain. 2009 Dec 15;147(1-3):60-6
pubmed: 19766392
Cochrane Database Syst Rev. 2015 Jan 28;1:CD005614
pubmed: 25629804
Arthritis Res Ther. 2009;11(3):227
pubmed: 19519925
Acupunct Med. 2020 Aug;38(4):211-226
pubmed: 32026725
Osteoarthritis Cartilage. 2014 Mar;22(3):363-88
pubmed: 24462672
BMJ. 2004 Dec 4;329(7478):1317
pubmed: 15561731
Scand J Rheumatol Suppl. 1987;65:85-9
pubmed: 3479839
Zhongguo Zhen Jiu. 2017 Oct 12;37(10):1027-34
pubmed: 29354968
Arthritis Rheum. 1995 Nov;38(11):1541-6
pubmed: 7488273
Lancet. 2005 Jul 9-15;366(9480):136-43
pubmed: 16005336
Trials. 2019 Jan 25;20(1):79
pubmed: 30683147
Am J Chin Med. 2017;45(5):965-985
pubmed: 28659033
Ann Rheum Dis. 1957 Dec;16(4):494-502
pubmed: 13498604
Phys Med Rehabil Clin N Am. 2001 Aug;12(3):507-27
pubmed: 11478185
J Intern Med. 2004 Aug;256(2):91-100
pubmed: 15257721
Acupunct Med. 2008 Mar;26(1):17-26
pubmed: 18356795
J Am Acad Orthop Surg. 2013 Sep;21(9):571-6
pubmed: 23996988
BMC Musculoskelet Disord. 2015 Jul 30;16:174
pubmed: 26223312
Knee. 2008 Oct;15(5):390-5
pubmed: 18620863
Phys Ther. 1987 Sep;67(9):1342-7
pubmed: 3628487
J Pain Res. 2018 Nov 08;11:2797-2808
pubmed: 30510442
Int J Clin Exp Med. 2015 Oct 15;8(10):18981-9
pubmed: 26770523
Arch Phys Med Rehabil. 2001 Mar;82(3):396-402
pubmed: 11245764
Cell Physiol Biochem. 2016;39(6):2331-2340
pubmed: 27832623
J Pain. 2018 May;19(5):515-527
pubmed: 29325883
Biol Psychiatry. 2003 Apr 15;53(8):754-60
pubmed: 12706959
Medicine (Baltimore). 2019 Jul;98(28):e16301
pubmed: 31305415