The TP53 mutation rate differs in breast cancers that arise in women with high or low mammographic density.

Breast cancer Cancer genomics

Journal

NPJ breast cancer
ISSN: 2374-4677
Titre abrégé: NPJ Breast Cancer
Pays: United States
ID NLM: 101674891

Informations de publication

Date de publication:
2020
Historique:
received: 05 01 2020
accepted: 13 07 2020
entrez: 18 8 2020
pubmed: 18 8 2020
medline: 18 8 2020
Statut: epublish

Résumé

Mammographic density (MD) influences breast cancer risk, but how this is mediated is unknown. Molecular differences between breast cancers arising in the context of the lowest and highest quintiles of mammographic density may identify the mechanism through which MD drives breast cancer development. Women diagnosed with invasive or in situ breast cancer where MD measurement was also available (

Identifiants

pubmed: 32802943
doi: 10.1038/s41523-020-00176-7
pii: 176
pmc: PMC7414106
doi:

Types de publication

Journal Article

Langues

eng

Pagination

34

Informations de copyright

© The Author(s) 2020.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing interests.

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Auteurs

Dane Cheasley (D)

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC Australia.
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC Australia.

Lisa Devereux (L)

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC Australia.
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC Australia.
Lifepool, Peter MacCallum Cancer Centre, Melbourne, VIC Australia.

Siobhan Hughes (S)

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC Australia.

Carolyn Nickson (C)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC Australia.
Cancer Research Division, Cancer Council NSW, Sydney, NSW Australia.
Sydney School of Public Health, University of Sydney, Sydney, NSW Australia.

Pietro Procopio (P)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC Australia.
Cancer Research Division, Cancer Council NSW, Sydney, NSW Australia.
Sydney School of Public Health, University of Sydney, Sydney, NSW Australia.

Grant Lee (G)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC Australia.

Na Li (N)

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC Australia.

Vicki Pridmore (V)

BreastScreen Victoria, Carlton South, VIC Australia.

Kenneth Elder (K)

Department of Surgery, University of Melbourne, Melbourne, VIC Australia.
The Royal Melbourne and Royal Women's Hospitals, Parkville, VIC Australia.
The Edinburgh Breast Unit, Western General Hospital, Edinburgh, UK.

G Bruce Mann (G)

Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC Australia.
Department of Surgery, University of Melbourne, Melbourne, VIC Australia.
The Royal Melbourne and Royal Women's Hospitals, Parkville, VIC Australia.

Tanjina Kader (T)

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC Australia.
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC Australia.

Simone M Rowley (SM)

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC Australia.

Stephen B Fox (SB)

Department of Pathology, Peter MacCallum Cancer Centre, and University of Melbourne, Melbourne, VIC Australia.

David Byrne (D)

Department of Pathology, Peter MacCallum Cancer Centre, and University of Melbourne, Melbourne, VIC Australia.

Hugo Saunders (H)

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC Australia.

Kenji M Fujihara (KM)

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC Australia.

Belle Lim (B)

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC Australia.
Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.

Kylie L Gorringe (KL)

Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC Australia.
Cancer Genetics and Genomics Program, Peter MacCallum Cancer Centre, Melbourne, VIC Australia.

Ian G Campbell (IG)

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC Australia.
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC Australia.

Classifications MeSH