Adrenal Corticomedullary Mixed Tumor Associated With the
FGFR4-G388R variant
adrenal gland
corticomedullary mixed tumor
Journal
Journal of the Endocrine Society
ISSN: 2472-1972
Titre abrégé: J Endocr Soc
Pays: United States
ID NLM: 101697997
Informations de publication
Date de publication:
01 Sep 2020
01 Sep 2020
Historique:
received:
28
04
2020
accepted:
16
07
2020
entrez:
18
8
2020
pubmed:
18
8
2020
medline:
18
8
2020
Statut:
epublish
Résumé
Adrenal corticomedullary mixed tumors (CMMTs) are extremely rare; with only 20 cases being reported to date, the pathogenesis has remained elusive. A 31-year-old woman developed gestational hypertension with psychiatric disturbances persistent to postpartum and was diagnosed with pheochromocytoma, for which adrenalectomy was performed. Histological findings showed mixed adrenocortical adenoma and pheochromocytoma. Double immunostaining of inhibin and INSM1 (insulinoma-associated protein 1) showed that the 2 tumor components had distinct functional properties. Exome analysis of peripheral leukocytes and tumor (singular, as anatomically it is only 1 mass) revealed a homozygous germline
Identifiants
pubmed: 32803097
doi: 10.1210/jendso/bvaa101
pii: bvaa101
pmc: PMC7417000
doi:
Types de publication
Case Reports
Langues
eng
Pagination
bvaa101Informations de copyright
© Endocrine Society 2020.
Références
Int J Urol. 2012 Dec;19(12):1123-4
pubmed: 22835027
Endocr Relat Cancer. 2018 Mar;25(3):R131-R152
pubmed: 29233839
Ann Endocrinol (Paris). 2009 Dec;70(6):473-6
pubmed: 19878923
Endocr J. 2013;60(3):329-36
pubmed: 23257735
Ann Diagn Pathol. 2011 Jun;15(3):185-9
pubmed: 20952294
Surg Today. 2013 Nov;43(11):1232-9
pubmed: 23435808
PLoS Genet. 2011 Dec;7(12):e1002400
pubmed: 22174695
Nature. 2015 Dec 24;528(7583):570-4
pubmed: 26675719
Ann Diagn Pathol. 2001 Oct;5(5):304-8
pubmed: 11598859
BMC Endocr Disord. 2017 Feb 13;17(1):9
pubmed: 28193212
J Cell Biochem. 2018 Nov;119(10):8260-8270
pubmed: 29943847
Mol Cell Endocrinol. 2014 Mar 5;383(1-2):111-7
pubmed: 24325867
Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):12997-13002
pubmed: 30514817
Endocr Pract. 2012 May-Jun;18(3):e37-42
pubmed: 22548942
Updates Surg. 2013 Jun;65(2):161-4
pubmed: 22228558