Bisphosphonate-Induced Deterioration of Osteomalacia in Undiagnosed Adult Fanconi Syndrome.
ANALYSIS/QUANTITATION OF BONE
ANTIRESORPTIVES
BONE HISTOMORPHOMETRY
BONE SCINTIGRAPHY
DISEASES AND DISORDERS OF/RELATED TO BONE
OSTEOMALACIA AND RICKETS
THERAPEUTICS
Journal
JBMR plus
ISSN: 2473-4039
Titre abrégé: JBMR Plus
Pays: England
ID NLM: 101707013
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
21
02
2020
revised:
28
04
2020
accepted:
26
05
2020
entrez:
18
8
2020
pubmed:
18
8
2020
medline:
18
8
2020
Statut:
epublish
Résumé
We describe two women with a misdiagnosed fracturing bone disease who were treated erroneously with i.v. zoledronate. Over the next year, they suffered marked clinical and radiographic deterioration in skeletal disease. Both were eventually diagnosed with hypophosphatemic osteomalacia secondary to acquired Fanconi syndrome (caused by light-chain myeloma in one case and tenofovir treatment in the other). Appropriate treatment with phosphate supplementation was instituted with clinical improvement. These cases illustrate the importance of not missing osteomalacia in adults presenting with fractures, and the potentially damaging effects of treatment with long-acting inhibitors of bone resorption in these circumstances. © 2020 The Authors.
Identifiants
pubmed: 32803107
doi: 10.1002/jbm4.10374
pii: JBM410374
pmc: PMC7422711
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10374Informations de copyright
© 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.
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