Nox4 Expression Is Not Required for OVX-Induced Osteoblast Senescence and Bone Loss in Mice.
NOX4
OSTEOBLAST
SENESCENCE
SEX STEROID DEFICIENCY
Journal
JBMR plus
ISSN: 2473-4039
Titre abrégé: JBMR Plus
Pays: England
ID NLM: 101707013
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
12
02
2020
revised:
04
05
2020
accepted:
09
05
2020
entrez:
18
8
2020
pubmed:
18
8
2020
medline:
18
8
2020
Statut:
epublish
Résumé
Estrogen deficiency and aging play critical roles in the pathophysiology of bone as a result of increased oxidative stress. It has been suggested that prevention of NADPH oxidase- (Nox-) dependent accumulation of ROS may be an approach to potentially minimize bone loss caused by these conditions. Using ovariectomized (OVX) and Nox4 gene-deletion mouse models, we investigated the role of Nox4 in OVX-induced bone loss and osteoblast senescence signaling. Six-month-old WT C57Bl6 mice were allocated to a sham control group, OVX, and OVX plus E2 treatment group for 8 weeks. Decreased bone mass including BMD and BMC were found in the OVX group compared with the sham control (
Identifiants
pubmed: 32803108
doi: 10.1002/jbm4.10376
pii: JBM410376
pmc: PMC7422714
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10376Informations de copyright
© 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.
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