LRRK2 to the rescue of damaged endomembranes.
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
pubmed:
18
8
2020
medline:
7
4
2021
entrez:
18
8
2020
Statut:
ppublish
Résumé
Mutations in several genes encoding for lysosomal proteins are involved in Parkinson's disease (PD). In this issue, Herbst et al (2020) show that PD-related leucine-rich repeat kinase 2 (LRRK2) is activated in response to pathogen or membranolytic drug-induced damage of phagolysosomes and lysosomes in macrophages, and regulates endolysosomal homeostasis by controlling the balance between membrane repair and degradation.
Identifiants
pubmed: 32803793
doi: 10.15252/embj.2020106162
pmc: PMC7507336
doi:
Substances chimiques
LRRK2 protein, human
EC 2.7.11.1
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
EC 2.7.11.1
Types de publication
News
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
e106162Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2020 The Authors.
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