Thiolated PVP-Amphotericin B Complexes: An Innovative Approach toward Highly Mucoadhesive Gels for Mucosal Leishmaniasis Treatment.

Amphotericin B / pharmacology Caco-2 Cells Gels Humans Leishmaniasis Povidone Sulfhydryl Compounds

Journal

Biomacromolecules
ISSN: 1526-4602
Titre abrégé: Biomacromolecules
Pays: United States
ID NLM: 100892849

Informations de publication

Date de publication:
14 09 2020
Historique:
pubmed: 18 8 2020
medline: 22 6 2021
entrez: 18 8 2020
Statut: ppublish

Résumé

The aim of this study was to synthesize polymeric excipients that can form mucoadhesive hydrogels containing amphotericin B (AmB) for the treatment of mucosal leishmaniasis. 2-(2-Acryloylaminoethyldisulfanyl)-nicotinic acid (ACENA) was copolymerized with

Identifiants

DOI: 10.1021/acs.biomac.0c00699 PMID: 32803961
pubmed: 32803961
doi: 10.1021/acs.biomac.0c00699
doi:

Substances chimiques

Gels 0
Sulfhydryl Compounds 0
Amphotericin B 7XU7A7DROE
Povidone FZ989GH94E

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3658-3667

Auteurs

Aamir Jalil (A)

Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.

Mulazim Hussain Asim (MH)

Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Department of Pharmaceutics, Faculty of Pharmacy, University of Sargodha, 40100 Sargodha, Pakistan.

Iram Shahzadi (I)

Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.

Momin Khan (M)

Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25000, Pakistan.

Barbara Matuszczak (B)

Center for Chemistry and Biomedicine, Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
ORCID: 0000-0002-4507-8739

Andreas Bernkop-Schnürch (A)

Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
ORCID: 0000-0003-4187-8277

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Lactones › Amphotéricine B › Thiolated PVP-Amphotericin B Complexes: An...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › Thiolated PVP-Amphotericin B Complexes: An...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Thiolated PVP-Amphotericin B Complexes: An...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Thiolated PVP-Amphotericin B Complexes: An...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Infections de la peau › Dermatoses parasitaires › Leishmaniose › Thiolated PVP-Amphotericin B Complexes: An...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Polyvinyles › Povidone › Thiolated PVP-Amphotericin B Complexes: An...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiols › Thiolated PVP-Amphotericin B Complexes: An...