Initial
Animals
Bacterial Outer Membrane Proteins
/ metabolism
Benzoates
/ pharmacology
Disease Models, Animal
Escherichia coli Proteins
/ metabolism
Female
Humans
Hydrazines
/ pharmacology
Male
Mice
Multienzyme Complexes
/ metabolism
Osteosarcoma
/ drug therapy
Pyrazoles
/ pharmacology
Xenograft Model Antitumor Assays
Eltrombopag
osteosarcoma
patient derived xenograft
Journal
Pediatric hematology and oncology
ISSN: 1521-0669
Titre abrégé: Pediatr Hematol Oncol
Pays: England
ID NLM: 8700164
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
pubmed:
18
8
2020
medline:
3
6
2021
entrez:
18
8
2020
Statut:
ppublish
Résumé
Eltrombopag is a small molecule, thrombopoietin receptor agonist approved for the treatment of patients with aplastic anemia and chronic immune thrombocytopenia. It is also a polyvalent cation chelator and inhibits leukemia cell proliferation via reduction of intracellular iron. The
Identifiants
pubmed: 32804009
doi: 10.1080/08880018.2020.1802539
pmc: PMC8670012
mid: NIHMS1761983
doi:
Substances chimiques
Bacterial Outer Membrane Proteins
0
Benzoates
0
Escherichia coli Proteins
0
Hydrazines
0
Multienzyme Complexes
0
Pyrazoles
0
envZ protein, E coli
EC 2.7.3.-
eltrombopag
S56D65XJ9G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8-13Subventions
Organisme : NCI NIH HHS
ID : U01 CA199221
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA199222
Pays : United States
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