Modulating Lipoprotein Transcellular Transport and Atherosclerotic Plaque Formation in ApoE
ATP Binding Cassette Transporter 1
/ genetics
Animals
Anti-Inflammatory Agents
/ chemistry
Apolipoproteins E
/ deficiency
Atherosclerosis
/ drug therapy
Diet, High-Fat
Interleukin-1beta
/ metabolism
Lipoproteins, LDL
/ chemistry
Liposomes
/ chemistry
Macrophages
/ cytology
Methotrexate
/ chemistry
Mice
Mice, Inbred C57BL
Mice, Knockout
Nanomedicine
Nanoparticles
/ chemistry
Particle Size
Phosphatidylethanolamines
/ chemistry
RAW 264.7 Cells
atherosclerosis
foam cells
inflammation
low-density lipoprotein transport
nanomedicine
Journal
ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991
Informations de publication
Date de publication:
26 Aug 2020
26 Aug 2020
Historique:
pubmed:
19
8
2020
medline:
23
2
2021
entrez:
19
8
2020
Statut:
ppublish
Résumé
Macrophage inflammation and maturation into foam cells, following the engulfment of oxidized low-density lipoproteins (oxLDL), are major hallmarks in the onset and progression of atherosclerosis. Yet, chronic treatments with anti-inflammatory agents, such as methotrexate (MTX), failed to modulate disease progression, possibly for the limited drug bioavailability and plaque deposition. Here, MTX-lipid conjugates, based on 1,2-distearoyl-
Identifiants
pubmed: 32805983
doi: 10.1021/acsami.0c12202
pmc: PMC7453397
doi:
Substances chimiques
ATP Binding Cassette Transporter 1
0
Anti-Inflammatory Agents
0
Apolipoproteins E
0
Interleukin-1beta
0
Lipoproteins, LDL
0
Liposomes
0
Phosphatidylethanolamines
0
oxidized low density lipoprotein
0
1,2-distearoylphosphatidylethanolamine
1G4B5265CQ
Methotrexate
YL5FZ2Y5U1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
37943-37956Subventions
Organisme : British Heart Foundation
ID : PG/19/84/34771
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/13/5/30177
Pays : United Kingdom
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