Luotonin A and Its Derivatives as Novel Antiviral and Antiphytopathogenic Fungus Agents.

Antiviral Agents / chemistry Drug Design Fungi / drug effects Fungicides, Industrial / chemistry Plant Diseases / virology Pyrroles / chemistry Quinones / chemistry Structure-Activity Relationship Tobacco Mosaic Virus / drug effects
antiviral activity fungicidal activity lead discovery luotonin A mode of action structure optimization

Journal

Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755

Informations de publication

Date de publication:
19 Aug 2020
Historique:
pubmed: 19 8 2020
medline: 22 1 2021
entrez: 19 8 2020
Statut: ppublish

Résumé

Plant diseases caused by viruses and fungi have posed a serious threat to global agricultural production. The discovery of new leads based on natural products is an important way to innovate pesticides. In this work, natural product luotonin A was found to have good antiviral activity against tobacco mosaic virus (TMV) for the first time. A series of luotonin A derivatives were designed, synthesized, and evaluated for their antiviral activities and fungicidal activities systematically. Most compounds displayed better antiviral activities against TMV than commercial ribavirin. Compounds

Identifiants

DOI: 10.1021/acs.jafc.0c04278 PMID: 32806124
pubmed: 32806124
doi: 10.1021/acs.jafc.0c04278
doi:

Substances chimiques

Antiviral Agents 0
Fungicides, Industrial 0
Pyrroles 0
Quinones 0
luotonin A 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8764-8773

Auteurs

Yanan Hao (Y)

Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, China.
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China.

Kaihua Wang (K)

State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China.

Ziwen Wang (Z)

Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, China.
ORCID: 0000-0001-9798-7021

Yuxiu Liu (Y)

State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China.

Dejun Ma (D)

State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China.

Qingmin Wang (Q)

State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China.
ORCID: 0000-0002-6062-3766

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Luotonin A and Its Derivatives as Novel...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Luotonin A and Its Derivatives as Novel...
questionsmedicales.fr › Eucaryotes › Champignons › Luotonin A and Its Derivatives as Novel...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Fongicides industriels › Luotonin A and Its Derivatives as Novel...
questionsmedicales.fr › Phénomènes physiologiques des plantes › Maladies des plantes › Luotonin A and Its Derivatives as Novel...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrroles › Luotonin A and Its Derivatives as Novel...
questionsmedicales.fr › Composés chimiques organiques › Quinones › Luotonin A and Its Derivatives as Novel...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Luotonin A and Its Derivatives as Novel...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Tobamovirus › Virus de la mosaïque du tabac › Luotonin A and Its Derivatives as Novel...