Microbiota-Derived Metabolites in Tumor Progression and Metastasis.
metastasis
microbiota-derived metabolites
tumor microenvironment
tumor progression
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Aug 2020
12 Aug 2020
Historique:
received:
09
07
2020
revised:
06
08
2020
accepted:
10
08
2020
entrez:
19
8
2020
pubmed:
19
8
2020
medline:
23
2
2021
Statut:
epublish
Résumé
Microbial communities and human cells, through a dynamic crosstalk, maintain a mutualistic relationship that contributes to the maintenance of cellular metabolism and of the immune and neuronal systems. This dialogue normally occurs through the production and regulation of hormonal intermediates, metabolites, secondary metabolites, proteins, and toxins. When the balance between host and microbiota is compromised, the dynamics of this relationship change, creating favorable conditions for the development of diseases, including cancers. Microbiome metabolites can be important modulators of the tumor microenvironment contributing to regulate inflammation, proliferation, and cell death, in either a positive or negative way. Recent studies also highlight the involvement of microbiota metabolites in inducing epithelial-mesenchymal transition, thus favoring the setup of the metastatic niche. An investigation of microbe-derived metabolites in "liquid" human samples, such as plasma, serum, and urine, provide further information to clarify the relationship between host and microbiota.
Identifiants
pubmed: 32806665
pii: ijms21165786
doi: 10.3390/ijms21165786
pmc: PMC7460823
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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