Characterization of IgA Deposition in the Kidney of Patients with IgA Nephropathy and Minimal Change.
IgA nephropathy with minimal change disease
KM55
double immunofluorescent staining
galactose-deficient IgA1
nephrotic syndrome
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
12 Aug 2020
12 Aug 2020
Historique:
received:
05
07
2020
revised:
05
08
2020
accepted:
09
08
2020
entrez:
19
8
2020
pubmed:
19
8
2020
medline:
19
8
2020
Statut:
epublish
Résumé
Approximately 5% of patients with IgA nephropathy (IgAN) exhibit mild mesangial lesions with acute onset nephrotic syndrome and diffuse foot process effacement representative of minimal change disease (MCD). It is not clear whether these unusual cases of IgAN with MCD (IgAN-MCD) are variant types of IgAN or coincidental deposition of IgA in patients with MCD. In a retrospective multicenter cohort study of 18 hospitals in Korea, we analyzed 46 patients with IgAN-MCD. Patients with endocapillary proliferation, segmental sclerosis, and crescent were excluded, and the clinical features and prognosis of IgAN-MCD were compared with those of pure MCD. In addition, we performed galactose-deficient IgA1 (KM55) staining to characterize IgAN-MCD. Among the 21,697 patients with glomerulonephritis enrolled in the database, 46 patients (0.21%) were diagnosed with IgAN-MCD, and 1610 patients (7.4%) with pure MCD. The 46 patients with IgAN-MCD accounted for 0.6% of primary IgAN patients (
Identifiants
pubmed: 32806730
pii: jcm9082619
doi: 10.3390/jcm9082619
pmc: PMC7464421
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : the National Research Foundation of Korea by the korean government
ID : 2018M3A9E8078807
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