[The trabecular meshwork: Structure, function and clinical implications. A review of the littérature (French translation of the article)].

Le trabéculum : structure, fonction et implications cliniques. Une revue de la littérature.
Glaucoma / etiology Humans Intraocular Pressure / physiology Optic Nerve Diseases / pathology Trabecular Meshwork / chemistry
Angle iridocornéen Aqueous humor Cellules trabéculaires Chirurgie du glaucome Glaucoma Glaucoma medications Glaucoma surgery Glaucome Glaucome cortico-induit Glaucome pigmentaire Glaucome primitif à angle ouvert Glaucome pseudoexfoliatif Glaucome secondaire Humeur aqueuse Hypertonie oculaire Intraocular pressure Iridocorneal angle Ocular hypertension Pigmentary glaucoma Pression intraoculaire Primary open angle glaucoma Pseudoexfoliative glaucoma Secondary glaucoma Steroid-induced glaucoma Trabecular meshwork Trabecular meshwork cells Trabeculoplasty Trabéculoplastie Trabéculum Traitement hypotonisant

Journal

Journal francais d'ophtalmologie
ISSN: 1773-0597
Titre abrégé: J Fr Ophtalmol
Pays: France
ID NLM: 7804128

Informations de publication

Date de publication:
Oct 2020
Historique:
received: 17 04 2020
revised: 17 04 2020
accepted: 22 04 2020
pubmed: 19 8 2020
medline: 4 11 2020
entrez: 19 8 2020
Statut: ppublish

Résumé

Glaucoma is a blinding optic neuropathy, the main risk factor for which is increased intraocular pressure (IOP). The trabecular meshwork, located within the iridocorneal angle, is the main pathway for drainage of aqueous humor (AH) out of the eye, and its dysfunction is responsible for the IOP elevation. The trabecular meshwork is a complex, fenestrated, three-dimensional structure composed of trabecular meshwork cells (TMC) interdigitated into a multilayered organization within the extracellular matrix (ECM). The purpose of this literature review is to provide an overview of current understanding of the trabecular meshwork and its pathophysiology in glaucoma. Thus, we will present the main anatomical and cellular bases for the regulation of aqueous humor outflow resistance, the pathophysiological mechanisms involved in trabecular dysfunction in the various types of glaucoma, as well as current and future therapeutic strategies targeting the trabecular meshwork.

Identifiants

DOI: 10.1016/j.jfo.2020.04.022 PMID: 32807552
pubmed: 32807552
pii: S0181-5512(20)30298-9
doi: 10.1016/j.jfo.2020.04.022
pii:
doi:

Types de publication

Journal Article Review

Langues

fre

Sous-ensembles de citation

IM

Pagination

779-793

Informations de copyright

Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Auteurs

J Buffault (J)

Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, IHU FOReSIGHT, 28, rue de Charenton, 75012 Paris, France. Electronic address: juliettebuffault@hotmail.fr.

A Labbé (A)

Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, IHU FOReSIGHT, 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, hôpital Ambroise-Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France; Inserm, CNRS, institut de la vision, Sorbonne université, 17, rue Moreau, 75012 Paris, France.

P Hamard (P)

Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, IHU FOReSIGHT, 28, rue de Charenton, 75012 Paris, France.

F Brignole-Baudouin (F)

Inserm, CNRS, institut de la vision, Sorbonne université, 17, rue Moreau, 75012 Paris, France; Service de biologie médicale, centre hospitalier national d'ophtalmologie des Quinze-Vingts, IHU FOReSIGHT, 28, rue de Charenton, 75012 Paris, France.

C Baudouin (C)

Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, IHU FOReSIGHT, 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, hôpital Ambroise-Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France; Inserm, CNRS, institut de la vision, Sorbonne université, 17, rue Moreau, 75012 Paris, France.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'oeil › Hypertension oculaire › Glaucome › [The trabecular meshwork: Structure, function...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › [The trabecular meshwork: Structure, function...
questionsmedicales.fr › Phénomènes physiologiques oculaires › Pression intraoculaire › [The trabecular meshwork: Structure, function...
questionsmedicales.fr › Maladies de l'oeil › Atteintes du nerf optique › [The trabecular meshwork: Structure, function...
questionsmedicales.fr › Organes des sens › Oeil › Pôle antérieur du bulbe oculaire › Réseau trabéculaire de la sclère › [The trabecular meshwork: Structure, function...