The different faces of the NLRP3 inflammasome in cutaneous Leishmaniasis: A review.
Cutaneous leishmaniasis
Human CL
IL-18
IL-1β
Murine CL
NLRP3 inflammasome
Journal
Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
29
04
2020
revised:
03
08
2020
accepted:
08
08
2020
pubmed:
19
8
2020
medline:
19
2
2022
entrez:
19
8
2020
Statut:
ppublish
Résumé
Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease caused by Protozoa of the genus Leishmania. Clinical manifestations of this disease are the result of a complex interplay of diverse factors, including the genetic background and the immune status of the host. Understanding the impact of these factors on the CL pathology may provide new targets to manage the infection and improve clinical outcome. The NLRP3 inflammasome, an innate immune complex of several cell types, seems to be involved in the CL physiopathology. Current studies of its role show contradictory effects of this complex on the evolution of Leishmania infection in mice and humans. In this review, we discuss the data regarding different roles of the NLRP3 inflammasome in murine and human CL.
Identifiants
pubmed: 32807586
pii: S1043-4666(20)30264-7
doi: 10.1016/j.cyto.2020.155248
pii:
doi:
Substances chimiques
Inflammasomes
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
155248Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.