Decontamination efficacy of sodium hypochlorite solutions for poliovirus.
Biosafety
Decontamination
Disinfectant efficacy
Polio vaccine production
Poliovirus
Sodium hypochlorite
Surface
Virucidal activity
Journal
Biologicals : journal of the International Association of Biological Standardization
ISSN: 1095-8320
Titre abrégé: Biologicals
Pays: England
ID NLM: 9004494
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
28
05
2020
revised:
24
07
2020
accepted:
26
07
2020
pubmed:
19
8
2020
medline:
10
8
2021
entrez:
19
8
2020
Statut:
ppublish
Résumé
Effective decontamination procedures are critical to the successful manufacture and control of poliovirus vaccines to minimize the risk to personnel and the environment. Polio viruses have been reported to be more resistant to disinfectants than many other viruses. We assessed the efficacy of sodium hypochlorite-containing disinfectants for decontamination for three poliovirus serotypes to implement decontamination procedures that are fully compliant with the WHO GAP III and Health authorities' requirements. A 10.4 log reduction was observed with a 0.63% sodium hypochlorite solution in a suspension with high protein and high poliovirus concentrations diluted 10-fold compared with a 6 log reduction in an undiluted sample. Treatment efficacy increased with sodium hypochlorite content and decreased with sample protein content. The surface tests showed that two 1-min treatments, 5-min apart, with a 0.63% Chl sodium hypochlorite solution effectively reduced the concentration of all poliovirus serotypes by 10 log
Identifiants
pubmed: 32807609
pii: S1045-1056(20)30087-7
doi: 10.1016/j.biologicals.2020.07.007
pii:
doi:
Substances chimiques
Disinfectants
0
Solutions
0
Sodium Hypochlorite
DY38VHM5OD
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
75-80Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.