High levels of ubidecarenone (oxidized CoQ
Animals
Cell Cycle Checkpoints
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Drug Delivery Systems
Female
Glioma
/ drug therapy
Humans
Lipids
/ chemistry
Mice
NIH 3T3 Cells
Nanoparticles
/ chemistry
Oxidation-Reduction
Pharmaceutical Preparations
/ chemistry
Rats, Wistar
Superoxides
/ metabolism
Ubiquinone
/ administration & dosage
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 08 2020
17 08 2020
Historique:
received:
18
12
2019
accepted:
04
08
2020
entrez:
19
8
2020
pubmed:
19
8
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Metabolic reprogramming in cancer cells, vs. non-cancer cells, elevates levels of reactive oxygen species (ROS) leading to higher oxidative stress. The elevated ROS levels suggest a vulnerability to excess prooxidant loads leading to selective cell death, a therapeutically exploitable difference. Co-enzyme Q
Identifiants
pubmed: 32807842
doi: 10.1038/s41598-020-70969-0
pii: 10.1038/s41598-020-70969-0
pmc: PMC7431533
doi:
Substances chimiques
Lipids
0
Pharmaceutical Preparations
0
Superoxides
11062-77-4
Ubiquinone
1339-63-5
coenzyme Q10
EJ27X76M46
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13899Références
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