p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy-lysosomal pathway and coordinate cell cycle and cell growth.
Amino Acids
/ metabolism
Autophagy
/ physiology
Cell Cycle
/ physiology
Cell Line
Cell Line, Tumor
Cell Proliferation
/ physiology
HEK293 Cells
HeLa Cells
Humans
Lysosomes
/ metabolism
Proliferating Cell Nuclear Antigen
/ metabolism
Signal Transduction
/ physiology
Starvation
/ metabolism
TOR Serine-Threonine Kinases
/ metabolism
Journal
Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
09
01
2018
accepted:
06
07
2020
pubmed:
19
8
2020
medline:
31
10
2020
entrez:
19
8
2020
Statut:
ppublish
Résumé
Autophagy is a catabolic process whereby cytoplasmic components are degraded within lysosomes, allowing cells to maintain energy homeostasis during nutrient depletion. Several studies reported that the CDK inhibitor p27
Identifiants
pubmed: 32807902
doi: 10.1038/s41556-020-0554-4
pii: 10.1038/s41556-020-0554-4
doi:
Substances chimiques
Amino Acids
0
Proliferating Cell Nuclear Antigen
0
p27 antigen
0
MTOR protein, human
EC 2.7.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1076-1090Commentaires et corrections
Type : CommentIn
Type : ErratumIn
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