Opportunistic Invasive Infection by Group A Streptococcus During Anti-Interleukin-6 Immunotherapy.
IL-6
adverse events
group A Streptococcus
immunotherapy
sepsis
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
08 04 2021
08 04 2021
Historique:
received:
18
05
2020
accepted:
07
08
2020
pubmed:
19
8
2020
medline:
11
2
2022
entrez:
19
8
2020
Statut:
ppublish
Résumé
Invasive group A Streptococcus (GAS) in immunocompetent individuals is largely linked to hypervirulent strains. Congenital immunodeficiencies and those acquired from chronic disease or immunosuppressant drugs also increase risk of severe illness. We recovered GAS from the blood of a patient receiving a biologic inhibitor of interleukin 6 (IL-6). Growth of this serotype M4 isolate in human blood or a murine bacteremia model was promoted by interleukin 1 or IL-6 inhibition. Hyperinvasive M1T1 GAS was unaffected by IL-6 in both models. These findings based on a natural experiment introduce IL-6 signaling deficiencies as a risk factor for invasive GAS.
Identifiants
pubmed: 32808035
pii: 5893614
doi: 10.1093/infdis/jiaa511
pmc: PMC8030709
doi:
Substances chimiques
Interleukin-6
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1260-1264Subventions
Organisme : NIAID NIH HHS
ID : K22 AI130223
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
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