Hypermetabolism in critically ill patients with COVID-19 and the effects of hypothermia: A case series.
Case report
Coronavirus (COVID-19)
Hypercapnia
Hypothermia
Hypoxia
Metabolism
Journal
Metabolism open
ISSN: 2589-9368
Titre abrégé: Metabol Open
Pays: England
ID NLM: 101767753
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
17
06
2020
revised:
21
07
2020
accepted:
24
07
2020
entrez:
19
8
2020
pubmed:
19
8
2020
medline:
19
8
2020
Statut:
epublish
Résumé
We have observed that critically ill patients with COVID-19 are in an extreme hypermetabolic state. This may be a major contributing factor to the extraordinary ventilatory and oxygenation demands seen in these patients. We aimed to quantify the extent of the hypermetabolic state and report the clinical effect of the use of hypothermia to decrease the metabolic demand in these patients. Mild hypothermia was applied on four critically ill patients with COVID-19 for 48 h. Metabolic rates, carbon dioxide production and oxygen consumption were measured by indirect calorimetry. The average resting energy expenditure (REE) was 299% of predicted. Mild hypothermia decreased the REE on average of 27.0% with resultant declines in CO Our case series demonstrates the extent of hypermetabolism in COVID-19 critical illness and suggests that mild hypothermia reduces the metabolic rate, improves hypercapnia and hypoxia in critically ill patients with COVID-19.
Sections du résumé
BACKGROUND
BACKGROUND
We have observed that critically ill patients with COVID-19 are in an extreme hypermetabolic state. This may be a major contributing factor to the extraordinary ventilatory and oxygenation demands seen in these patients. We aimed to quantify the extent of the hypermetabolic state and report the clinical effect of the use of hypothermia to decrease the metabolic demand in these patients.
METHODS
METHODS
Mild hypothermia was applied on four critically ill patients with COVID-19 for 48 h. Metabolic rates, carbon dioxide production and oxygen consumption were measured by indirect calorimetry.
RESULTS
RESULTS
The average resting energy expenditure (REE) was 299% of predicted. Mild hypothermia decreased the REE on average of 27.0% with resultant declines in CO
CONCLUSION
CONCLUSIONS
Our case series demonstrates the extent of hypermetabolism in COVID-19 critical illness and suggests that mild hypothermia reduces the metabolic rate, improves hypercapnia and hypoxia in critically ill patients with COVID-19.
Identifiants
pubmed: 32808941
doi: 10.1016/j.metop.2020.100046
pii: S2589-9368(20)30026-8
pii: 100046
pmc: PMC7382710
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100046Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
None.
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