Substantia nigra pars reticulata-mediated sleep and motor activity regulation.
bicuculline
infusion
microdialysis
muscimol
restless legs syndrome
Journal
Sleep
ISSN: 1550-9109
Titre abrégé: Sleep
Pays: United States
ID NLM: 7809084
Informations de publication
Date de publication:
21 01 2021
21 01 2021
Historique:
received:
14
04
2020
revised:
01
08
2020
pubmed:
19
8
2020
medline:
27
4
2021
entrez:
19
8
2020
Statut:
ppublish
Résumé
The substantia nigra pars reticulata (SNR) is a major output nucleus of the basal ganglia. Animal studies have shown that lesions of the SNR cause hyposomnia and motor hyperactivity, indicating that the SNR may play a role in the control of sleep and motor activity. Eight 8- to 10-week-old adult male Sprague-Dawley rats were used. After 3 days of baseline polysomnographic recording, dialysates were collected from the lateral SNR across natural sleep-wake states. Muscimol and bicuculline were microinfused into the lateral SNR. We found that GABA release in the lateral SNR is negatively correlated with slow wave sleep (SWS; R = -0.266, p < 0.01, n = 240) and positively correlated with waking (R = 0.265, p < 0.01, n = 240) in rats. Microinfusion of muscimol into the lateral SNR decreased sleep time and sleep quality, as well as eliciting motor hyperactivity in wake and increased periodic leg movement in SWS, while bicuculline infused into the lateral SNR increased sleep and decreased motor activity in SWS in rats. Muscimol infusion skewed the distribution of inter-movement intervals, with most between 10 and 20 s, while a flat distribution of intervals between 10 and 90 s was seen in baseline conditions. Activation of the lateral SNR is important for inducing sleep and inhibiting motor activity prior to and during sleep, and thus to the maintenance of sleep. Abnormal function of the lateral SNR may cause hyposomnia and motor hyperactivity in quiet wake and in sleep.
Identifiants
pubmed: 32808987
pii: 5893883
doi: 10.1093/sleep/zsaa151
pmc: PMC7819837
pii:
doi:
Substances chimiques
GABA Antagonists
0
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL148574
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS082242
Pays : United States
Informations de copyright
Published by Oxford University Press on behalf of Sleep Research Society (SRS) 2020.
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