The structure-based reaction mechanism of urease, a nickel dependent enzyme: tale of a long debate.
Catalytic mechanism
Crystal structure
Helicobacter pylori
Klebsiella aerogenes
Nickel
Sporosarcina pasteurii
Urease
Journal
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
ISSN: 1432-1327
Titre abrégé: J Biol Inorg Chem
Pays: Germany
ID NLM: 9616326
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
30
05
2020
accepted:
29
06
2020
pubmed:
19
8
2020
medline:
5
6
2021
entrez:
19
8
2020
Statut:
ppublish
Résumé
This review is an attempt to retrace the chronicle that starts from the discovery of the role of nickel as the essential metal ion in urease for the enzymatic catalysis of urea, a key step in the biogeochemical cycle of nitrogen on Earth, to the most recent progress in understanding the chemistry of this historical enzyme. Data and facts are presented through the magnifying lenses of the authors, using their best judgment to filter and elaborate on the many facets of the research carried out on this metalloenzyme over the years. The tale is divided in chapters that discuss and describe the results obtained in the subsequent leaps in the knowledge that led from the discovery of a biological role for Ni to the most recent advancements in the comprehension of the relationship between the structure and function of urease. This review is intended not only to focus on the bioinorganic chemistry of this beautiful metal-based catalysis, but also, and maybe primarily, to evoke inspiration and motivation to further explore the realm of bio-based coordination chemistry.
Identifiants
pubmed: 32809087
doi: 10.1007/s00775-020-01808-w
pii: 10.1007/s00775-020-01808-w
pmc: PMC7433671
doi:
Substances chimiques
Bacterial Proteins
0
Nickel
7OV03QG267
Urease
EC 3.5.1.5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
829-845Commentaires et corrections
Type : ErratumIn
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