Rational Design and Synthesis of Methyl-β-d-galactomalonyl Phenyl Esters as Potent Galectin-8

Binding Sites Cell Line, Tumor Computer Simulation Cytokines / genetics Drug Design Female Galactosides / chemical synthesis Galectins / antagonists & inhibitors Humans Molecular Docking Simulation Molecular Structure Protein Binding Thermodynamics

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
22 10 2020
Historique:
pubmed: 19 8 2020
medline: 29 12 2020
entrez: 19 8 2020
Statut: ppublish

Résumé

Galectin-8 is a β-galactoside-recognizing protein having an important role in the regulation of bone remodeling and cancer progression and metastasis. Methyl β-d-galactopyranoside malonyl aromatic esters have been designed to target and engage with particular amino acid residues of the galectin-8

Identifiants

DOI: 10.1021/acs.jmedchem.0c00602 PMID: 32809817
pubmed: 32809817
doi: 10.1021/acs.jmedchem.0c00602
doi:

Substances chimiques

Cytokines 0
Galactosides 0
Galectins 0
LGALS8 protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11573-11584

Auteurs

Brijesh Patel (B)

Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
ORCID: 0000-0002-8029-0356

Chandan Kishor (C)

Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
School of Chemistry and Molecular Bioscience, and Molecular Horizons, University of Wollongong, Wollongong, New South Wales 2522, Australia.
ORCID: 0000-0002-6328-1116

Todd A Houston (TA)

Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.

Hadas Shatz-Azoulay (H)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

Yehiel Zick (Y)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

Yaron Vinik (Y)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

Helen Blanchard (H)

Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
School of Chemistry and Molecular Bioscience, and Molecular Horizons, University of Wollongong, Wollongong, New South Wales 2522, Australia.
ORCID: 0000-0003-3372-5027

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Rational Design and Synthesis of...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Rational Design and Synthesis of...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Rational Design and Synthesis of...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Rational Design and Synthesis of...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Rational Design and Synthesis of...
questionsmedicales.fr › Glucides › Hétérosides › Galactoside › Rational Design and Synthesis of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lectines › Galectines › Rational Design and Synthesis of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Rational Design and Synthesis of...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Rational Design and Synthesis of...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Rational Design and Synthesis of...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Rational Design and Synthesis of...
questionsmedicales.fr › Phénomènes physiques › Thermodynamique › Rational Design and Synthesis of...