A guide to plasma membrane solute carrier proteins.
amino acids
cancer
cell surface
cellular metabolism
cellular transport
glucose
pH
physiology
plasma membrane
solute carrier transporter
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
07
08
2020
received:
27
03
2020
accepted:
17
08
2020
pubmed:
19
8
2020
medline:
22
7
2021
entrez:
19
8
2020
Statut:
ppublish
Résumé
This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily of transporter proteins and their roles in human cells. The SLC superfamily currently includes 458 transport proteins in 65 families that carry a wide variety of substances across cellular membranes. While members of this superfamily are found throughout cellular organelles, this review focuses on transporters expressed at the plasma membrane. At the cell surface, SLC proteins may be viewed as gatekeepers of the cellular milieu, dynamically responding to different metabolic states. With altered metabolism being one of the hallmarks of cancer, we also briefly review the roles that surface SLC proteins play in the development and progression of cancer through their influence on regulating metabolism and environmental conditions.
Identifiants
pubmed: 32810346
doi: 10.1111/febs.15531
pmc: PMC8246967
doi:
Substances chimiques
Membrane Transport Proteins
0
Solute Carrier Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2784-2835Informations de copyright
© 2020 The CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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