Outcomes of patients with end-stage kidney disease hospitalized with COVID-19.
COVID-19
ESKD
ESRD
dialysis
hemodialysis
peritoneal dialysis
Journal
Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
08
06
2020
revised:
28
07
2020
accepted:
30
07
2020
pubmed:
19
8
2020
medline:
22
12
2020
entrez:
19
8
2020
Statut:
ppublish
Résumé
Given the high risk of infection-related mortality, patients with end-stage kidney disease (ESKD) may be at increased risk with COVID-19. To assess this, we compared outcomes of patients with and without ESKD, hospitalized with COVID-19. This was a retrospective study of patients admitted with COVID-19 from 13 New York hospitals from March 1, 2020, to April 27, 2020, and followed through May 27, 2020. We measured primary outcome (in-hospital death), and secondary outcomes (mechanical ventilation and length of stay). Of 10,482 patients with COVID-19, 419 had ESKD. Patients with ESKD were older, had a greater percentage self-identified as Black, and more comorbid conditions. Patients with ESKD had a higher rate of in-hospital death than those without (31.7% vs 25.4%, odds ratio 1.38, 95% confidence interval 1.12 - 1.70). This increase rate remained after adjusting for demographic and comorbid conditions (adjusted odds ratio 1.37, 1.09 - 1.73). The odds of length of stay of seven or more days was higher in the group with compared to the group without ESKD in both the crude and adjusted analysis (1.62, 1.27 - 2.06; vs 1.57, 1.22 - 2.02, respectively). There was no difference in the odds of mechanical ventilation between the groups. Independent risk factors for in-hospital death for patients with ESKD were increased age, being on a ventilator, lymphopenia, blood urea nitrogen and serum ferritin. Black race was associated with a lower risk of death. Thus, among patients hospitalized with COVID-19, those with ESKD had a higher rate of in-hospital death compared to those without ESKD.
Identifiants
pubmed: 32810523
pii: S0085-2538(20)30945-5
doi: 10.1016/j.kint.2020.07.030
pmc: PMC7428720
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1530-1539Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK118017
Pays : United States
Investigateurs
Mersema Abate
(M)
Hugo Paz Andrade
(HP)
Richard L Barnett
(RL)
Alessandro Bellucci
(A)
Madhu C Bhaskaran
(MC)
Antonio G Corona
(AG)
Bessy Suyin Flores Chang
(BS)
Mark Finger
(M)
Steven Fishbane
(S)
Michael Gitman
(M)
Candice Halinski
(C)
Shamir Hasan
(S)
Azzour D Hazzan
(AD)
Susana Hong
(S)
Yuriy Khanin
(Y)
Aireen Kuan
(A)
Varun Madireddy
(V)
Deepa Malieckal
(D)
Abdulrahman Muzib
(A)
Gayatri Nair
(G)
Jia Hwei Ng
(JH)
Rushang Parikh
(R)
Daniel W Ross
(DW)
Vipulbhai Sakhiya
(V)
Mala Sachdeva
(M)
Richard Schwarz
(R)
Hitesh H Shah
(HH)
Purva Sharma
(P)
Pravin C Singhal
(PC)
Nupur N Uppal
(NN)
Rimda Wanchoo
(R)
Jamie S Hirsch
(JS)
Kenar D Jhaveri
(KD)
Vinay V Nair
(VV)
Informations de copyright
Copyright © 2020 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
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