Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice.
Alzheimer Disease
/ metabolism
Animals
Astrocytes
/ metabolism
Brain
/ metabolism
Calcium
/ metabolism
Endoplasmic Reticulum
/ metabolism
Energy Metabolism
Glycolysis
/ physiology
Hippocampus
/ metabolism
Homeostasis
Humans
Mice
Mice, Transgenic
Mitochondria
/ metabolism
Neurons
/ metabolism
Oxygen Consumption
/ physiology
Proteomics
Proteostasis
Reactive Oxygen Species
/ metabolism
Unfolded Protein Response
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
18 08 2020
18 08 2020
Historique:
received:
12
07
2020
accepted:
06
08
2020
revised:
01
08
2020
entrez:
20
8
2020
pubmed:
20
8
2020
medline:
13
4
2021
Statut:
epublish
Résumé
The pathogenesis of Alzheimer's disease (AD), a slowly-developing age-related neurodegenerative disorder, is a result of the action of multiple factors including deregulation of Ca
Identifiants
pubmed: 32811809
doi: 10.1038/s41419-020-02911-1
pii: 10.1038/s41419-020-02911-1
pmc: PMC7434916
doi:
Substances chimiques
Reactive Oxygen Species
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
645Références
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