Postpartum metabolic syndrome and high-sensitivity C-reactive protein after gestational hypertension and pre-eclampsia.
Adult
Biomarkers
/ blood
C-Reactive Protein
/ metabolism
Cardiovascular Diseases
/ epidemiology
Cohort Studies
Female
Humans
Hypertension, Pregnancy-Induced
/ blood
Kenya
/ epidemiology
Metabolic Syndrome
/ epidemiology
Postpartum Period
/ blood
Pre-Eclampsia
/ blood
Pregnancy
Pregnancy Complications
/ blood
Prospective Studies
Risk Factors
Cardiovascular
Gestational
High-sensitivity C-reactive protein
Metabolic syndrome
Postpartum
Pre-eclampsia
Journal
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
ISSN: 1879-3479
Titre abrégé: Int J Gynaecol Obstet
Pays: United States
ID NLM: 0210174
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
11
02
2020
revised:
24
06
2020
accepted:
17
08
2020
pubmed:
20
8
2020
medline:
11
3
2021
entrez:
20
8
2020
Statut:
ppublish
Résumé
To evaluate the association between metabolic syndrome (MetS) and high-sensitivity C-reactive protein (hsCRP), a biomarker of chronic inflammation and an independent predictor for cardiovascular disease overall and in subgroups of women with/without pre-eclampsia and gestational hypertension (GHT). A prospective cohort study was conducted in Nairobi, Kenya. Women with pre-eclampsia or GHT and normotensive women within 12 weeks postpartum underwent physical, anthropometric, fasting lipid profile, plasma glucose, and hsCRP measurements at 6 months postpartum. A generalized linear regression model with Poisson distribution adjusted for body mass index and age was used to estimate the association between elevated hsCRP and MetS overall and stratified by pre-eclampsia or GHT. In the 171 women included in the study, risk of elevated hsCRP (>3 mg/L) was greater among women with compared to those without MetS (adjusted relative risk [ARR] 1.70, 95% confidence interval [CI] 1.05-2.73, P=0.03) and was statistically significantly higher in the hypertensive (ARR 2.16 95% CI 1.01-4.62, P=0.04) but not in the normotensive (ARR 1.46, 95% CI 0.93-2.28) group. Increased risk of elevated hsCRP postpartum can guide longitudinal mechanistic and intervention studies to reduce postpartum cardiovascular morbidity in women with MetS, especially after pre-eclampsia or GHT.
Identifiants
pubmed: 32812650
doi: 10.1002/ijgo.13352
pmc: PMC7722223
mid: NIHMS1630715
doi:
Substances chimiques
Biomarkers
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
443-449Subventions
Organisme : NIH HHS
ID : D43 TW009580
Pays : United States
Organisme : FIC NIH HHS
ID : K43 TW010363
Pays : United States
Organisme : NIMH NIH HHS
Pays : United States
Organisme : NIH HHS
ID : K43 TW010363
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW009580
Pays : United States
Organisme : NIDA NIH HHS
Pays : United States
Informations de copyright
© 2020 International Federation of Gynecology and Obstetrics.
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