Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus.
Diabetic complication
HNA%
Nephropathy
Neuropathy
Oxidative stress
Retinopathy
Journal
Metabolism open
ISSN: 2589-9368
Titre abrégé: Metabol Open
Pays: England
ID NLM: 101767753
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
09
01
2020
revised:
03
03
2020
accepted:
10
03
2020
entrez:
20
8
2020
pubmed:
20
8
2020
medline:
20
8
2020
Statut:
epublish
Résumé
Albumin has an oxidized form, known as non-mercaptalbumin (HNA), which reflects systemic oxidative stress. The association between serum HNA levels and diabetic complications are yet to be reported. In this cross-sectional study, we investigated 164 diabetic subjects to assess the correlation between HNA% (the proportion in the total albumin) and various clinical parameters. HNA% was significantly associated with the severity of multiple complications including neuropathy (23.3 ± 4.1% vs 26.2 ± 5.1%) and nephropathy (24.1 ± 3.9%, 24.6 ± 4.2%, 28.5 ± 6.1%, 31.3 ± 5.7%, 37.8 ± 2.9%, stage 1/2/3/4/5, respectively). These findings highlight the universal importance of oxidative stress, indicating HNA% potential as a versatile marker of the severity of diabetic complications.
Identifiants
pubmed: 32812907
doi: 10.1016/j.metop.2020.100032
pii: S2589-9368(20)30012-8
pii: 100032
pmc: PMC7424782
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100032Informations de copyright
© 2020 The Authors.
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