Bacterial agents and changes in drug susceptibilities in cases of chronic dacryocystitis, Southern China.
Changes
Drug susceptibilities
Influencing factors
Lacrimal drainage
Microbiology
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
10
09
2019
accepted:
09
08
2020
pubmed:
20
8
2020
medline:
22
6
2021
entrez:
20
8
2020
Statut:
ppublish
Résumé
This study aimed to determine the susceptibility and the changes of bacterial agents of chronic dacryocystitis and determine the risk factors for bacterial prevalence and drug sensitivity to provide a reference for clinical selection of antibiotics. A case-control study was conducted using 112 patients with chronic dacryocystitis and 112 patients with non-infectious ophthalmopathy between August 2017 and April 2018. Lacrimal and conjunctival sac secretions were cultured for aerobic and anaerobic bacteria. Forty-five patients with chronic dacryocystitis between November 2014 and November 2015 were also included. Positive bacterial cultures were obtained from 61.9% and 50.9% of chronic dacryocystitis and non-infectious ophthalmopathy patients, but the detection rates for pathogenic bacteria were 18.3% and 2.7%, respectively (P > 0.001). Gram-negative and anaerobic bacteria were significantly more prevalent in the patient group compared with the control group (P = 0.001 and 0.005, respectively). Bacteria were detected at a significantly higher rate in patients with irritant symptoms (itch or foreign-body sensation) than in those without (OR = 9.333, P = 0.002), particularly Staphylococcus (OR = 9.783, P = 0.002). 11.6% (10/86) and 55.8% (48/86) showed resistance to levofloxacin and tobramycin, respectively. Compared with three years ago, the detection rate for Gram-positive cocci decreased from 51.1% to 27.8% (χ
Identifiants
pubmed: 32813193
doi: 10.1007/s10792-020-01545-8
pii: 10.1007/s10792-020-01545-8
doi:
Substances chimiques
Anti-Bacterial Agents
0
Pharmaceutical Preparations
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-10Subventions
Organisme : the Provincial Frontier and Key Technology Innovation special fund of Guangdong Province
ID : 2015B020227001
Organisme : the Guangzhou Science and Technology Program
ID : 201508020028
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