Size Does Matter: Litter Size Strongly Determines Adult Metabolism in Rodents.

Animals Litter Size Mice Obesity / metabolism Rats
developmental origins of health and disease insulin resistance litter size mouse models neonatal growth rate obesity

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
01 09 2020
Historique:
received: 13 03 2020
revised: 16 06 2020
accepted: 20 07 2020
pubmed: 20 8 2020
medline: 9 11 2021
entrez: 20 8 2020
Statut: ppublish

Résumé

In this essay, we highlight how litter size in rodents is a strong determinant of neonatal growth and long-term metabolic health. Based on these effects, we strongly advise that scientific articles that utilize rodent models for obesity and metabolic research should include information on the litter sizes in the study to increase the data transparency of such reports.

Identifiants

DOI: 10.1016/j.cmet.2020.07.014 PMID: 32814016
pubmed: 32814016
pii: S1550-4131(20)30372-7
doi: 10.1016/j.cmet.2020.07.014
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

334-340

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Marcela Parra-Vargas (M)

Institut de Recerca Sant Joan de Déu, Endocrinology, c/ Santa Rosa 39-57, 4ª planta, Esplugues, 08950 Barcelona, Spain.

Marta Ramon-Krauel (M)

Institut de Recerca Sant Joan de Déu, Endocrinology, c/ Santa Rosa 39-57, 4ª planta, Esplugues, 08950 Barcelona, Spain.

Carles Lerin (C)

Institut de Recerca Sant Joan de Déu, Endocrinology, c/ Santa Rosa 39-57, 4ª planta, Esplugues, 08950 Barcelona, Spain.

Josep C Jimenez-Chillaron (JC)

Institut de Recerca Sant Joan de Déu, Endocrinology, c/ Santa Rosa 39-57, 4ª planta, Esplugues, 08950 Barcelona, Spain. Electronic address: jjimenezc@fsjd.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Size Does Matter: Litter Size Strongly...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Gestation animale › Taille de la portée › Size Does Matter: Litter Size Strongly...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Size Does Matter: Litter Size Strongly...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Size Does Matter: Litter Size Strongly...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Size Does Matter: Litter Size Strongly...