Maternal stress or sleep during pregnancy are not reflected on telomere length of newborns.
Female
Humans
Infant, Newborn
Linear Models
Male
Pregnancy
Pregnancy Complications
/ physiopathology
Prenatal Exposure Delayed Effects
/ diagnosis
Self Report
Sleep Wake Disorders
/ physiopathology
Stress, Psychological
/ physiopathology
Surveys and Questionnaires
Telomere
/ genetics
Telomere Homeostasis
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
19 08 2020
19 08 2020
Historique:
received:
30
10
2019
accepted:
06
08
2020
entrez:
21
8
2020
pubmed:
21
8
2020
medline:
29
12
2020
Statut:
epublish
Résumé
Telomeres play an important role in maintaining chromosomal integrity. With each cell division, telomeres are shortened and leukocyte telomere length (LTL) has therefore been considered a marker for biological age. LTL is associated with various lifetime stressors and health-related outcomes. Transgenerational effects have been implicated in newborns, with maternal stress, depression, and anxiety predicting shorter telomere length at birth, possibly reflecting the intrauterine growth environment. Previous studies, with relatively small sample sizes, have reported an effect of maternal stress, BMI, and depression during pregnancy on the LTL of newborns. Here, we attempted to replicate previous findings on prenatal stress and newborn LTL in a sample of 1405 infants using a qPCR-based method. In addition, previous research has been expanded by studying the relationship between maternal sleep quality and LTL. Maternal prenatal stress, anxiety, depression, BMI, and self-reported sleep quality were evaluated with self-reported questionnaires. Despite sufficient power to detect similar or even considerably smaller effects than those previously reported in the literature, we were unable to replicate the previous correlation between maternal stress, anxiety, depression, or sleep with LTL. We discuss several possible reasons for the discrepancies between our findings and those previously described.
Identifiants
pubmed: 32814800
doi: 10.1038/s41598-020-71000-2
pii: 10.1038/s41598-020-71000-2
pmc: PMC7438332
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13986Références
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