Immune-evasive human islet-like organoids ameliorate diabetes.
Animals
B7-H1 Antigen
/ genetics
Cell Line
Diabetes Mellitus, Experimental
/ immunology
Epigenesis, Genetic
Female
Glucose
/ metabolism
Graft Rejection
Heterografts
Homeostasis
Humans
Immune Evasion
Immune Tolerance
Insulin Secretion
Islets of Langerhans
/ cytology
Islets of Langerhans Transplantation
Lymphocyte Activation
Male
Mice
Mice, Inbred NOD
Mice, SCID
Organoids
/ cytology
T-Lymphocytes
/ cytology
Wnt Signaling Pathway
/ drug effects
Wnt4 Protein
/ metabolism
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
17
12
2018
accepted:
18
05
2020
pubmed:
21
8
2020
medline:
20
1
2021
entrez:
21
8
2020
Statut:
ppublish
Résumé
Islets derived from stem cells hold promise as a therapy for insulin-dependent diabetes, but there remain challenges towards achieving this goal
Identifiants
pubmed: 32814902
doi: 10.1038/s41586-020-2631-z
pii: 10.1038/s41586-020-2631-z
pmc: PMC7872080
mid: NIHMS1595843
doi:
Substances chimiques
B7-H1 Antigen
0
CD274 protein, human
0
WNT4 protein, human
0
Wnt4 Protein
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
606-611Subventions
Organisme : NIDDK NIH HHS
ID : K01 DK120808
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NIH HHS
ID : S10 OD023689
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014195
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES010337
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK098085
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120480
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : ErratumIn
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