Association between circulating tumor necrosis factor receptors and oral bacterium in patients receiving hemodialysis: a cross-sectional study.
Aged
C-Reactive Protein
/ metabolism
Cross-Sectional Studies
Female
Humans
Kidney Failure, Chronic
/ blood
Male
Middle Aged
Mouth
/ microbiology
Periodontitis
/ blood
Porphyromonas gingivalis
Receptors, Tumor Necrosis Factor, Type I
/ blood
Receptors, Tumor Necrosis Factor, Type II
/ blood
Renal Dialysis
Saliva
/ microbiology
Chronic kidney disease
Hemodialysis
P. gingivalis
Periodontitis
TNF receptor
Journal
Clinical and experimental nephrology
ISSN: 1437-7799
Titre abrégé: Clin Exp Nephrol
Pays: Japan
ID NLM: 9709923
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
22
04
2020
accepted:
03
08
2020
pubmed:
21
8
2020
medline:
6
10
2021
entrez:
21
8
2020
Statut:
ppublish
Résumé
High levels of tumor necrosis factor (TNF) receptors (TNFRs; TNFR1 and TNFR2), markers of inflammation, have been reported as significant predictors of mortality in hemodialysis patients. Porphyromonas gingivalis is a major pathogenic bacterium involved in periodontitis, which induces systemic inflammation. We investigated the association between the abundance of P. gingivalis in saliva and serum TNFR levels in hemodialysis patients. A cross-sectional study was conducted on 121 hemodialysis patients visiting a clinic in the Tokyo metropolitan area. Medical interviews and examinations, comprehensive dental examinations, bacterial examinations for P. gingivalis in saliva, and measurements of circulating TNFR levels were conducted. Multiple linear regression analysis was performed to evaluate the association between the number of P. gingivalis and circulating TNFR levels. TNFR1 and TNFR2 were positively correlated with high-sensitivity C-reactive protein (hsCRP). Severe periodontitis was significantly associated with the number of P. gingivalis in saliva but not serum TNFR levels. The number of P. gingivalis was significantly associated with both TNFR1 and TNFR2 levels in sera after adjusting for age, sex, body mass index, smoking status, history of diabetes, prior cardiovascular disease events, serum levels of hsCRP and albumin, and severity of periodontitis [for TNFR1: coefficient 0.76, 95% confidence interval (CI) 0.14-1.37, p = 0.02; for TNFR2: coefficient 0.95, 95% CI 0.09-1.80, p = 0.03]. Circulating TNFR levels are associated with the number of P. gingivalis in saliva after adjusting for relevant clinical factors.
Sections du résumé
BACKGROUND
BACKGROUND
High levels of tumor necrosis factor (TNF) receptors (TNFRs; TNFR1 and TNFR2), markers of inflammation, have been reported as significant predictors of mortality in hemodialysis patients. Porphyromonas gingivalis is a major pathogenic bacterium involved in periodontitis, which induces systemic inflammation. We investigated the association between the abundance of P. gingivalis in saliva and serum TNFR levels in hemodialysis patients.
METHODS
METHODS
A cross-sectional study was conducted on 121 hemodialysis patients visiting a clinic in the Tokyo metropolitan area. Medical interviews and examinations, comprehensive dental examinations, bacterial examinations for P. gingivalis in saliva, and measurements of circulating TNFR levels were conducted. Multiple linear regression analysis was performed to evaluate the association between the number of P. gingivalis and circulating TNFR levels.
RESULTS
RESULTS
TNFR1 and TNFR2 were positively correlated with high-sensitivity C-reactive protein (hsCRP). Severe periodontitis was significantly associated with the number of P. gingivalis in saliva but not serum TNFR levels. The number of P. gingivalis was significantly associated with both TNFR1 and TNFR2 levels in sera after adjusting for age, sex, body mass index, smoking status, history of diabetes, prior cardiovascular disease events, serum levels of hsCRP and albumin, and severity of periodontitis [for TNFR1: coefficient 0.76, 95% confidence interval (CI) 0.14-1.37, p = 0.02; for TNFR2: coefficient 0.95, 95% CI 0.09-1.80, p = 0.03].
CONCLUSION
CONCLUSIONS
Circulating TNFR levels are associated with the number of P. gingivalis in saliva after adjusting for relevant clinical factors.
Identifiants
pubmed: 32816134
doi: 10.1007/s10157-020-01952-2
pii: 10.1007/s10157-020-01952-2
doi:
Substances chimiques
Receptors, Tumor Necrosis Factor, Type I
0
Receptors, Tumor Necrosis Factor, Type II
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
58-65Références
Sharma S, Sarnak MJ. Epidemiology: the global burden of reduced GFR: ESRD, CVD and mortality. Nat Rev Nephrol. 2017;13(8):447–8.
pubmed: 28626221
Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351(13):1296–305.
pubmed: 15385656
Himmelfarb J, Ikizler TA. Hemodialysis. N Engl J Med. 2010;363(19):1833–45.
pubmed: 21047227
Betjes MG. Immune cell dysfunction and inflammation in end-stage renal disease. Nat Rev Nephrol. 2013;9(5):255–65.
pubmed: 23507826
Ma L, Zhao S. Risk factors for mortality in patients undergoing hemodialysis: a systematic review and meta-analysis. Int J Cardiol. 2017;238:151–8.
pubmed: 28341375
Aukrust P, Sandberg WJ, Otterdal K, Vinge LE, Gullestad L, Yndestad A, et al. Tumor necrosis factor superfamily molecules in acute coronary syndromes. Ann Med. 2011;43(2):90–103.
pubmed: 21039303
Gohda T, Niewczas MA, Ficociello LH, Walker WH, Skupien J, Rosetti F, et al. Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. J Am Soc Nephrol. 2012;23(3):516–24.
pubmed: 22266664
pmcid: 3294299
Carlsson AC, Juhlin CC, Larsson TE, Larsson A, Ingelsson E, Sundström J, et al. Soluble tumor necrosis factor receptor 1 (sTNFR1) is associated with increased total mortality due to cancer and cardiovascular causes—findings from two community based cohorts of elderly. Atherosclerosis. 2014;237(1):236–42.
pubmed: 25255422
Carlsson AC, Nordquist L, Larsson TE, Carrero JJ, Larsson A, Lind L, et al. Soluble tumor necrosis factor receptor 1 is associated with glomerular filtration rate progression and incidence of chronic kidney disease in two community-based cohorts of elderly individuals. Cardiorenal Med. 2015;5(4):278–88.
pubmed: 26648944
pmcid: 4662300
Murakoshi M, Gohda T, Sonoda Y, Suzuki H, Tomino Y, Horikoshi S, et al. Effect of tonsillectomy with steroid pulse therapy on circulating tumor necrosis factor receptors 1 and 2 in IgA nephropathy. Clin Exp Nephrol. 2017;21(6):1068–74.
pubmed: 28389814
Gohda T, Maruyama S, Kamei N, Yamaguchi S, Shibata T, Murakoshi M, et al. Circulating TNF Receptors 1 and 2 predict mortality in patients with end-stage renal disease undergoing dialysis. Sci Rep. 2017;3(7):43520.
Speeckaert MM, Speeckaert R, Laute M, Vanholder R, Delanghe JR. Tumor necrosis factor receptors: biology and therapeutic potential in kidney diseases. Am J Nephrol. 2012;36(3):261–70.
pubmed: 22965073
Omote K, Gohda T, Murakoshi M, Sasaki Y, Kazuno S, Fujimura T, et al. Role of the TNF pathway in the progression of diabetic nephropathy in KK-A(y) mice. Am J Physiol Renal Physiol. 2014;306(11):F1335–47.
pubmed: 24647715
Al-Lamki RS, Mayadas TN. TNF receptors: signaling pathways and contribution to renal dysfunction. Kidney Int. 2015;87(2):281–96.
pubmed: 25140911
Niewczas MA, Gohda T, Skupien J, Smiles AM, Walker WH, Rosetti F, et al. Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol. 2012;23(3):507–15.
pubmed: 22266663
pmcid: 3294310
Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, et al. A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes. Nat Med. 2019;25(5):805–13.
pubmed: 31011203
pmcid: 31011203
Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366(9499):1809–20.
pubmed: 16298220
Paraskevas S, Huizinga JD, Loos BG. A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol. 2008;35(4):277–90.
pubmed: 18294231
Demmer RT, Trinquart L, Zuk A, Fu BC, Blomkvist J, Michalowicz BS, et al. The influence of anti-infective periodontal treatment on C-reactive protein: a systematic review and meta-analysis of randomized controlled trials. PLoS ONE. 2013;8(10):e77441.
pubmed: 24155956
pmcid: 3796504
Kshirsagar AV, Craig RG, Beck JD, Moss K, Offenbacher S, Kotanko P, et al. Severe periodontitis is associated with low serum albumin among patients on maintenance hemodialysis therapy. Clin J Am Soc Nephrol. 2007;2(2):239–44.
pubmed: 17699419
Chen LP, Chiang CK, Chan CP, Hung KY, Huang CS. Does periodontitis reflect inflammation and malnutrition status in hemodialysis patients? Am J Kidney Dis. 2006;47(5):815–22.
pubmed: 16632020
Franek E, Blaschyk R, Kolonko A, Mazur-Psonka L, Łangowska-Adamczyk H, Kokot F, et al. Chronic periodontitis in hemodialysis patients with chronic kidney disease is associated with elevated serum C-reactive protein concentration and greater intima-media thickness of the carotid artery. J Nephrol. 2006;19(3):346–51.
pubmed: 16874696
Cholewa M, Madziarska K, Radwan-Oczko M. The association between periodontal conditions, inflammation, nutritional status and calcium-phosphate metabolism disorders in hemodialysis patients. J Appl Oral Sci. 2018;26:e20170495.
pubmed: 30043933
pmcid: 6063464
Genco RJ, Borgnakke WS. Risk factors for periodontal disease. Periodontol 2000. 2013;62(1):59–94.
pubmed: 23574464
Reynolds MA. Modifiable risk factors in periodontitis: at the intersection of aging and disease. Periodontol 2000. 2014;64(1):7–19.
pubmed: 24320953
Thanakun S, Pornprasertsuk-Damrongsri S, Gokyu M, Kobayashi H, Izumi Y. Inverse association of plasma IgG antibody to aggregatibacter actinomycetemcomitans and high C-reactive protein levels in patients with metabolic syndrome and periodontitis. PLoS ONE. 2016;11(2):e0148638.
pubmed: 26871443
pmcid: 4752452
Sonoda Y, Gohda T, Suzuki Y, Omote K, Ishizaka M, Matsuoka J, et al. Circulating TNF receptors 1 and 2 are associated with the severity of renal interstitial fibrosis in IgA nephropathy. PLoS ONE. 2015;10(4):e0122212.
pubmed: 4393287
pmcid: 4393287
Gohda T, Nishizaki Y, Murakoshi M, Nojiri S, Yanagisawa N, Shibata T, et al. Clinical predictive biomarkers for normoalbuminuric diabetic kidney disease. Diabetes Res Clin Pract. 2018;141:62–8.
pubmed: 29729375
Page RC, Eke PI. Case definitions for use in population-based surveillance of periodontitis. J Periodontol. 2007;78(Suppl 7S):1387–99.
pubmed: 17608611
pmcid: 17608611
Korte DL, Kinney J. Personalized medicine: an update of salivary biomarkers for periodontal diseases. Periodontol 2000. 2016;70(1):26–37.
pubmed: 26662480
Bossola M. Xerostomia in patients on chronic hemodialysis: an update. Semin Dial. 2019;32(5):467–74.
pubmed: 31117154
Tervahartiala T, Koski H, Xu JW, Häyrinen-Immonen R, Hietanen J, Sorsa T, et al. Tumor necrosis factor-alpha and its receptors, p55 and p75, in gingiva of adult periodontitis. J Dent Res. 2001;80(6):1535–9.
pubmed: 11499508
Lockhart PB, Brennan MT, Sasser HC, Fox PC, Paster BJ, Bahrani-Mougeot FK. Bacteremia associated with toothbrushing and dental extraction. Circulation. 2008;117(24):3118–25.
pubmed: 18541739
pmcid: 2746717
Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015;15(1):30–44.
pubmed: 25534621
pmcid: 4276050
Nie P, Li Z, Wang Y, Zhang Y, Zhao M, Luo J, et al. Gut microbiome interventions in human health and diseases. Med Res Rev. 2019;39(6):2286–313.
pubmed: 30994937
Taneja V. Sex hormones determine immune response. Front Immunol. 2018;9:1931.
pubmed: 30210492
pmcid: 6119719
de Alencar JB, Zacarias JMV, Tsuneto PY, Souza VH, Silva COE, Visentainer JEL, et al. Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility. PLoS ONE. 2020;15(1):e0227905.
pubmed: 31978095
pmcid: 6980600
Petersilka GJ, Ehmke B, Flemmig TF. Antimicrobial effects of mechanical debridement. Periodontol 2000. 2002;28:56–71.
pubmed: 12013348