Dietary nitrate supplementation does not influence thermoregulatory or cardiovascular strain in older individuals during severe ambient heat stress.
Aged
Aged, 80 and over
Aging
/ drug effects
Arterial Pressure
/ drug effects
Beta vulgaris
/ chemistry
Body Temperature Regulation
/ drug effects
Cardiovascular System
/ drug effects
Dietary Supplements
Female
Fruit and Vegetable Juices
Heart Rate
/ drug effects
Heat Stress Disorders
/ drug therapy
Heat-Shock Response
/ drug effects
Humans
Male
Middle Aged
Nitrates
/ administration & dosage
Regional Blood Flow
/ drug effects
Skin
/ drug effects
Skin Temperature
/ drug effects
Sweating
/ drug effects
Vasodilation
/ drug effects
beetroot juice
blood pressure
cardiac function
core temperature
skin blood flow
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
08
06
2020
accepted:
17
08
2020
pubmed:
21
8
2020
medline:
21
10
2021
entrez:
21
8
2020
Statut:
ppublish
Résumé
What is the central question of this study? Does dietary nitrate supplementation with beetroot juice attenuate thermoregulatory and cardiovascular strain in older adults during severe heat stress? What is the main finding and its importance? A 7-day nitrate supplementation regimen lowered resting mean arterial pressure in thermoneutral conditions. During heat stress, core and mean skin temperatures, vasodilatory responses, sweat loss, heart rate and left ventricular function were unchanged, and mean arterial pressure was only transiently reduced, post-supplementation. These data suggest nitrate supplementation with beetroot juice does not mitigate thermoregulatory or cardiovascular strain in heat-stressed older individuals. This study tested the hypothesis that dietary nitrate supplementation with concentrated beetroot juice attenuates thermoregulatory and cardiovascular strain in older individuals during environmental heat stress. Nine healthy older individuals (six females, three males; aged 67 ± 5 years) were exposed to 42.5 ± 0.1°C and 34.0 ± 0.5% relative humidity conditions for 120 min before (CON) and after 7 days of dietary nitrate supplementation with concentrated beetroot juice (BRJ; 280 ml, ∼16.8 mmol of nitrate daily). Core and skin temperatures, body mass changes (indicative of whole-body sweat loss), skin blood flow and cutaneous vascular conductance, forearm blood flow and vascular conductance, heart rate, arterial blood pressures and indices of cardiac function were measured. The 7-day beetroot juice regimen increased plasma nitrate/nitrite levels from 27.4 ± 15.2 to 477.0 ± 102.5 μmol l
Identifiants
pubmed: 32816341
doi: 10.1113/EP088834
pmc: PMC7731583
mid: NIHMS1642137
doi:
Substances chimiques
Nitrates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1730-1741Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM068865
Pays : United States
Organisme : Natural Sciences and Engineering Research Council of Canada Postdoctoral Fellowship
Organisme : U.S. Department of Defense
ID : W81XWH-15-1-0647
Informations de copyright
© 2020 The Authors. Experimental Physiology © 2020 The Physiological Society.
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