Ferroptosis: a new unexpected chance to treat metastatic melanoma?
AKR
Ferroptosis
NRF2
lipid-ROS
melanoma
Journal
Cell cycle (Georgetown, Tex.)
ISSN: 1551-4005
Titre abrégé: Cell Cycle
Pays: United States
ID NLM: 101137841
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
pubmed:
21
8
2020
medline:
18
11
2021
entrez:
21
8
2020
Statut:
ppublish
Résumé
Human skin melanoma is one of the most aggressive and difficult to treat human malignancies, with an increasing incidence over the years. While the resection of the early diagnosed primary tumor remains the best clinical approach, advanced/metastatic melanoma still remains with a poor prognosis. Indeed, although enormous progress in the therapeutic treatment of human tumors has been made in recent years, patients affected by metastatic melanoma are still poorly affected by these clinical advances. Therefore, new valuable therapeutic approaches are urgently needed, to design and define effective treatments to consistently increase the overall survival rate of patients affected by this malignancy. In this review we summarize the main signaling pathways studied to kill human skin melanoma, and introduce the ferroptotic cell death as a new pathway to be explored to eradicate this tumor.
Identifiants
pubmed: 32816618
doi: 10.1080/15384101.2020.1806426
pmc: PMC7553499
doi:
Substances chimiques
Antineoplastic Agents
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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