The muscle reflex and chemoreflex interaction: ventilatory implications for the exercising human.
control of breathing
exercise hyperpnea
group III and IV muscle afferents
hypercapnia
hypoxia
Journal
Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Titre abrégé: J Appl Physiol (1985)
Pays: United States
ID NLM: 8502536
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
pubmed:
21
8
2020
medline:
24
6
2021
entrez:
21
8
2020
Statut:
ppublish
Résumé
We examined the interactive influence of the muscle reflex (MR) and the chemoreflex (CR) on the ventilatory response to exercise. Eleven healthy subjects (5 women/6 men) completed three bouts of constant-load single-leg knee-extension exercise in a control trial and an identical trial conducted with lumbar intrathecal fentanyl to attenuate neural feedback from lower-limb group III/IV muscle afferents. The exercise during the two trials was performed while breathing ambient air ([Formula: see text] ~97%, [Formula: see text]~84 mmHg, [Formula: see text] ~32 mmHg, pH ~7.39), or under normocapnic hypoxia ([Formula: see text] ~79%, [Formula: see text] ~43 mmHg, [Formula: see text] ~33 mmHg, pH ~7.39) or normoxic hypercapnia ([Formula: see text] ~98%, [Formula: see text] ~105 mmHg, [Formula: see text] ~50 mmHg, pH ~7.26). During coactivation of the MR and the hypoxia-induced CR (O
Identifiants
pubmed: 32816637
doi: 10.1152/japplphysiol.00449.2020
pmc: PMC7654695
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
691-700Subventions
Organisme : VA
ID : E1697-R
Pays : United States
Organisme : VA
ID : E6910-R
Pays : United States
Organisme : VA
ID : E9275-L
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL091830
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL-139451
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL-091830
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL116579
Pays : United States
Organisme : RRD VA
ID : I01 RX003343
Pays : United States
Organisme : VA
ID : E1433-P
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL-116579
Pays : United States
Organisme : VA
ID : E1572-P
Pays : United States
Références
Exp Physiol. 2014 Feb;99(2):368-80
pubmed: 24142455
J Physiol. 2011 Nov 1;589(Pt 21):5299-309
pubmed: 21878520
J Physiol. 1983 Sep;342:383-97
pubmed: 6631740
Compr Physiol. 2012 Jan;2(1):743-77
pubmed: 23728984
J Appl Physiol Respir Environ Exerc Physiol. 1983 Jul;55(1 Pt 1):105-12
pubmed: 6309712
J Physiol. 2011 Aug 1;589(Pt 15):3855-66
pubmed: 21646407
J Physiol. 2010 Jul 1;588(Pt 13):2455-71
pubmed: 20421288
J Physiol. 2009 Jan 15;587(1):271-83
pubmed: 19015193
J Neurosci. 2005 Feb 23;25(8):1965-78
pubmed: 15728836
J Appl Physiol Respir Environ Exerc Physiol. 1980 Jun;48(6):1065-76
pubmed: 6769888
J Appl Physiol (1985). 2018 Jul 1;125(1):215-225
pubmed: 29565769
Am J Physiol Regul Integr Comp Physiol. 2019 Jun 1;316(6):R727-R734
pubmed: 30943058
Physiology (Bethesda). 2018 Jul 1;33(4):281-297
pubmed: 29897299
J Physiol. 1971 Jul;215(3):789-804
pubmed: 5090995
Compr Physiol. 2012 Jan;2(1):221-54
pubmed: 23728974
Exp Physiol. 2019 Nov;104(11):1605-1621
pubmed: 31429500
Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1492-500
pubmed: 21317304
Am J Physiol Regul Integr Comp Physiol. 2014 Jun 15;306(12):R934-40
pubmed: 24740653
Circ Res. 1977 Sep;41(3):332-41
pubmed: 196781
Am J Physiol Regul Integr Comp Physiol. 2020 Jan 1;318(1):R30-R37
pubmed: 31664869
J Appl Physiol. 1972 Dec;33(6):813-9
pubmed: 4643864
Circ Res. 1982 Nov;51(5):624-36
pubmed: 7139881
J Neurophysiol. 2013 May;109(9):2374-81
pubmed: 23427306
Exp Physiol. 2019 Oct;104(10):1472-1481
pubmed: 31206823
J Physiol. 1972 Jul;224(1):173-86
pubmed: 5039977
Exp Physiol. 2014 Feb;99(2):414-26
pubmed: 24163425
Am J Respir Crit Care Med. 2012 Oct 1;186(7):606-15
pubmed: 22822019
Cell. 2009 Jun 12;137(6):1148-59
pubmed: 19524516
Exp Physiol. 2012 Feb;97(2):208-18
pubmed: 22058167
J Physiol. 1975 Sep;250(2):431-41
pubmed: 1177147
J Physiol. 1967 Jun;190(3):425-41
pubmed: 6051780
Am J Physiol Regul Integr Comp Physiol. 2003 Dec;285(6):R1287-304
pubmed: 12881202
J Appl Physiol. 1966 Jan;21(1):242-6
pubmed: 5903918
J Physiol. 1973 Dec;235(2):423-36
pubmed: 4763996
J Physiol. 2015 Sep 15;593(18):4225-43
pubmed: 26171601
J Appl Physiol Respir Environ Exerc Physiol. 1978 Oct;45(4):557-64
pubmed: 711573
J Appl Physiol (1985). 1990 Jun;68(6):2466-72
pubmed: 2384427
Respir Physiol. 2000 Feb;119(2-3):199-208
pubmed: 10722863
Am J Phys Med. 1967 Feb;46(1):582-647
pubmed: 5337072
J Physiol. 1987 Feb;383:9-18
pubmed: 3116207
J Appl Physiol (1985). 1999 Jan;86(1):174-80
pubmed: 9887128
J Appl Physiol (1985). 2009 May;106(5):1564-73
pubmed: 19246650
Science. 1981 Feb 20;211(4484):844-6
pubmed: 7466362
J Appl Physiol (1985). 1993 May;74(5):2365-72
pubmed: 8335569
Neuron. 2015 Sep 2;87(5):946-61
pubmed: 26335642
Exp Physiol. 2010 Jan;95(1):194-201
pubmed: 19801386
J Neurophysiol. 2008 Sep;100(3):1184-201
pubmed: 18509077
J Appl Physiol (1985). 2003 Jul;95(1):43-8
pubmed: 12547840
J Appl Physiol (1985). 2010 Apr;108(4):989-94
pubmed: 20075260
Am J Physiol Regul Integr Comp Physiol. 2014 May;306(9):R693-700
pubmed: 24573180
Respir Physiol Neurobiol. 2010 Nov 30;174(1-2):37-42
pubmed: 20674807
J Appl Physiol (1985). 2010 Oct;109(4):966-76
pubmed: 20634355
Respir Physiol Neurobiol. 2010 Oct 31;173(3):288-97
pubmed: 20206717
J Physiol. 2018 Apr 15;596(8):1373-1384
pubmed: 29388218
J Physiol. 2020 Jun;598(12):2311-2321
pubmed: 32170732
Compr Physiol. 2014 Oct;4(4):1511-62
pubmed: 25428853
Acta Physiol Scand. 1965 Mar;63:343-50
pubmed: 14324070
Eur Respir J. 2014 Aug;44(2):495-512
pubmed: 24925922
Ann N Y Acad Sci. 1977;301:243-61
pubmed: 270920