Illuminating the allosteric modulation of the calcium-sensing receptor.
G protein-coupled receptor
allosteric modulator
amino acids
calcium
nutrient sensing
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
pubmed:
21
8
2020
medline:
30
10
2020
entrez:
21
8
2020
Statut:
ppublish
Résumé
Many membrane receptors are regulated by nutrients. However, how these nutrients control a single receptor remains unknown, even in the case of the well-studied calcium-sensing receptor CaSR, which is regulated by multiple factors, including ions and amino acids. Here, we developed an innovative cell-free Förster resonance energy transfer (FRET)-based conformational CaSR biosensor to clarify the main conformational changes associated with activation. By allowing a perfect control of ambient nutrients, this assay revealed that Ca
Identifiants
pubmed: 32817431
pii: 1922231117
doi: 10.1073/pnas.1922231117
pmc: PMC7474691
doi:
Substances chimiques
Ligands
0
Receptors, Calcium-Sensing
0
Receptors, G-Protein-Coupled
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21711-21722Déclaration de conflit d'intérêts
The authors declare no competing interest.
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