Tissue alkaline phosphatase activity and expression in an experimental infant swine model of cardiopulmonary bypass with deep hypothermic circulatory arrest.
Acute kidney injury
Acute lung injury
Cardiac surgery
Congenital heart disease
Endotoxin
Inflammation
Neonate
Organ injury
Pediatric
Therapy
Journal
Journal of inflammation (London, England)
ISSN: 1476-9255
Titre abrégé: J Inflamm (Lond)
Pays: England
ID NLM: 101232234
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
04
2020
accepted:
30
07
2020
entrez:
21
8
2020
pubmed:
21
8
2020
medline:
21
8
2020
Statut:
epublish
Résumé
Infant cardiac surgery with cardiopulmonary bypass results in decreased circulating alkaline phosphatase that is associated with poor postoperative outcomes. Bovine intestinal alkaline phosphatase infusion represents a novel therapy for post-cardiac surgery organ injury. However, the effects of cardiopulmonary bypass and bovine-intestinal alkaline phosphatase infusion on tissue-level alkaline phosphatase activity/expression are unknown. Infant pigs ( Tissue alkaline phosphatase activity varied significantly across organs with the highest levels found in the kidney and small intestine. Cardiopulmonary bypass with deep hypothermic circulatory arrest resulted in decreased kidney alkaline phosphatase activity and increased lung alkaline phosphatase activity, with no significant changes in the other organs. Alkaline phosphatase mRNA expression was increased in both the lung and the ileum. The highest dose of bovine intestinal alkaline phosphatase resulted in increased kidney and liver tissue alkaline phosphatase activity. Changes in alkaline phosphatase activity after cardiopulmonary bypass with deep hypothermic circulatory arrest and bovine intestinal alkaline phosphatase delivery are tissue specific. Kidneys, lung, and ileal alkaline phosphatase appear most affected by cardiopulmonary bypass with deep hypothermic circulatory arrest and further research is warranted to determine the mechanism and biologic importance of these changes.
Sections du résumé
BACKGROUND
BACKGROUND
Infant cardiac surgery with cardiopulmonary bypass results in decreased circulating alkaline phosphatase that is associated with poor postoperative outcomes. Bovine intestinal alkaline phosphatase infusion represents a novel therapy for post-cardiac surgery organ injury. However, the effects of cardiopulmonary bypass and bovine-intestinal alkaline phosphatase infusion on tissue-level alkaline phosphatase activity/expression are unknown.
METHODS
METHODS
Infant pigs (
RESULTS
RESULTS
Tissue alkaline phosphatase activity varied significantly across organs with the highest levels found in the kidney and small intestine. Cardiopulmonary bypass with deep hypothermic circulatory arrest resulted in decreased kidney alkaline phosphatase activity and increased lung alkaline phosphatase activity, with no significant changes in the other organs. Alkaline phosphatase mRNA expression was increased in both the lung and the ileum. The highest dose of bovine intestinal alkaline phosphatase resulted in increased kidney and liver tissue alkaline phosphatase activity.
CONCLUSIONS
CONCLUSIONS
Changes in alkaline phosphatase activity after cardiopulmonary bypass with deep hypothermic circulatory arrest and bovine intestinal alkaline phosphatase delivery are tissue specific. Kidneys, lung, and ileal alkaline phosphatase appear most affected by cardiopulmonary bypass with deep hypothermic circulatory arrest and further research is warranted to determine the mechanism and biologic importance of these changes.
Identifiants
pubmed: 32817746
doi: 10.1186/s12950-020-00256-2
pii: 256
pmc: PMC7422466
doi:
Types de publication
Journal Article
Langues
eng
Pagination
27Subventions
Organisme : American Heart Association-American Stroke Association
ID : 17IRG33410724
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL123634
Pays : United States
Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
Références
Shock. 2004 Aug;22(2):174-9
pubmed: 15257092
J Biol Chem. 1984 Jan 10;259(1):574-82
pubmed: 6142888
J Pharmacol Exp Ther. 2013 Jan;344(1):2-7
pubmed: 23131595
Pediatr Crit Care Med. 2016 Feb;17(2):e76-80
pubmed: 26669644
Nutr Rev. 2010 Jun;68(6):323-32
pubmed: 20536777
Crit Care. 2012 May 22;16(3):R91
pubmed: 22616947
Pediatr Crit Care Med. 2015 Jan;16(1):37-44
pubmed: 25162512
Front Immunol. 2017 Aug 03;8:897
pubmed: 28824625
J Thorac Cardiovasc Surg. 2008 Nov;136(5):1280-7; discussion 1287-8
pubmed: 19026816
Nat Med. 2011 Nov 07;17(11):1391-401
pubmed: 22064429
Shock. 2019 Mar;51(3):328-336
pubmed: 29664834
Clin Chem. 1982 Oct;28(10):2007-16
pubmed: 6751596
Circulation. 2003 Feb 25;107(7):996-1002
pubmed: 12600913
Gut. 2009 Mar;58(3):379-87
pubmed: 18852260
Handb Exp Pharmacol. 2009;(193):443-70
pubmed: 19639291
Nutr Rev. 2019 Oct 1;77(10):710-724
pubmed: 31086953
Ann Thorac Surg. 2018 Feb;105(2):637-643
pubmed: 29275827
Urol Int. 1981;36(3):178-93
pubmed: 6116305
Purinergic Signal. 2012 Sep;8(3):437-502
pubmed: 22555564
Clin Chem. 1989 Apr;35(4):664-7
pubmed: 2702751
Circulation. 2012 Jan 3;125(1):e2-e220
pubmed: 22179539
Vet Med Nauki. 1980;17(1):3-7
pubmed: 7414928
JAMA. 2018 Nov 20;320(19):1998-2009
pubmed: 30357272
J Pharmacol Exp Ther. 2003 Nov;307(2):737-44
pubmed: 12970380
Kidney Int. 1989 Oct;36(4):617-25
pubmed: 2681932
PLoS One. 2017 Apr 27;12(4):e0175936
pubmed: 28448526
Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G467-75
pubmed: 20489044
Nutr Res Rev. 2016 Jun;29(1):60-90
pubmed: 27176552
Kidney Blood Press Res. 2018;43(5):1409-1424
pubmed: 30212831
J Pediatr. 2017 Nov;190:49-55.e2
pubmed: 29144270
PLoS One. 2016 Jul 06;11(7):e0158981
pubmed: 27384524
J Biol Chem. 2003 Apr 11;278(15):13468-79
pubmed: 12560324
Int Immunopharmacol. 2020 Apr;81:106297
pubmed: 32062078
Proteomics Clin Appl. 2014 Oct;8(9-10):715-31
pubmed: 25092613
Am J Physiol. 1997 Dec;273(6):F849-56
pubmed: 9435672
J Thorac Cardiovasc Surg. 2012 Dec;144(6):1323-8, 1328.e1-2
pubmed: 22503201
Biochim Biophys Acta. 2013 Dec;1832(12):2044-56
pubmed: 23899605
Inflamm Bowel Dis. 2010 Jul;16(7):1180-6
pubmed: 19885903
Biochim Biophys Acta. 2002 Jan 2;1586(1):71-80
pubmed: 11781151
Crit Care. 2012 Aug 20;16(4):R160
pubmed: 22906145
Curr Opin Nephrol Hypertens. 2012 Jan;21(1):24-32
pubmed: 22080856
Kaibogaku Zasshi. 1996 Jun;71(3):183-94
pubmed: 8831185
Recent Pat Inflamm Allergy Drug Discov. 2009 Nov;3(3):214-20
pubmed: 19534671
World J Gastroenterol. 2014 Nov 14;20(42):15650-6
pubmed: 25400448
Crit Rev Clin Lab Sci. 1994;31(3):197-293
pubmed: 7818774
J Biol Chem. 2013 Sep 20;288(38):27315-26
pubmed: 23897810
Eur J Clin Pharmacol. 2009 Apr;65(4):393-402
pubmed: 19048243
Histochemistry. 1984;80(2):145-8
pubmed: 6370929
J Surg Res. 2010 Sep;163(1):79-85
pubmed: 20599220
N Engl J Med. 2012 Dec 13;367(24):2322-33
pubmed: 23234515
Sci Rep. 2019 Oct 2;9(1):14175
pubmed: 31578351
Toxicol Appl Pharmacol. 1995 Sep;134(1):170-4
pubmed: 7676452
Vet Med Nauki. 1979;16(10):41-7
pubmed: 549264
Am J Physiol. 1995 Apr;268(4 Pt 1):G663-72
pubmed: 7733291
Am J Physiol Gastrointest Liver Physiol. 2006 Feb;290(2):G377-85
pubmed: 16223948
Dig Dis Sci. 2002 Dec;47(12):2704-10
pubmed: 12498289
Anesthesiology. 2002 Jul;97(1):215-52
pubmed: 12131125
Tissue Barriers. 2015 Apr 03;3(1-2):e970936
pubmed: 25838978
Am J Physiol Renal Physiol. 2014 Sep 15;307(6):F680-5
pubmed: 24990899
Am Heart J. 1974 Nov;88(5):553-6
pubmed: 4421995
BMC Genomics. 2014 Oct 21;15:916
pubmed: 25331815
PLoS One. 2014 Apr 18;9(4):e95382
pubmed: 24748324
Circulation. 2018 Mar 20;137(12):e67-e492
pubmed: 29386200
J Am Soc Nephrol. 2011 Jan;22(1):14-20
pubmed: 21209250
Am J Physiol. 1998 Sep;275(3):G572-83
pubmed: 9724271
Int J Pharm. 2015 Nov 10;495(1):122-131
pubmed: 26325308
J Biol Chem. 1992 May 25;267(15):10625-30
pubmed: 1316905
J Surg Res. 2016 May 1;202(1):225-34
pubmed: 27083970
Circulation. 2005 Nov 8;112(19):2912-20
pubmed: 16275880
Purinergic Signal. 2017 Sep;13(3):363-386
pubmed: 28547381
Clin J Am Soc Nephrol. 2018 Jul 6;13(7):1113-1123
pubmed: 29523680
Br J Pharmacol. 2015 Oct;172(20):4932-45
pubmed: 26222228
Circulation. 2007 Oct 16;116(16):1784-94
pubmed: 17909107
Toxicol Appl Pharmacol. 2016 Dec 15;313:88-96
pubmed: 27760303
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14298-303
pubmed: 20660763
Vet Pathol. 2012 Mar;49(2):344-56
pubmed: 21441112
Biochim Biophys Acta. 2008 May;1783(5):673-94
pubmed: 18302942
Crit Care Med. 2009 Feb;37(2):417-23, e1
pubmed: 19114895
Crit Care. 2012 Jan 23;16(1):R14
pubmed: 22269279
Clin Biochem. 2002 Sep;35(6):455-61
pubmed: 12413606
Anesthesiology. 2001 May;94(5):745-53; discussion 5A
pubmed: 11388523
Int J Exp Pathol. 2003 Jun;84(3):135-44
pubmed: 12974943
Shock. 2002 Dec;18(6):561-6
pubmed: 12462566
Clin Chim Acta. 1990 Jan 15;186(2):133-50
pubmed: 2178806
Mol Cell Biol. 2003 Nov;23(21):7525-30
pubmed: 14560000
JACC Cardiovasc Interv. 2009 May;2(5):373-83
pubmed: 19463458
J Cell Biol. 2009 Jun 29;185(7):1285-98
pubmed: 19564407
Pediatr Neonatol. 2019 Feb;60(1):3-11
pubmed: 29891225
Asian Cardiovasc Thorac Ann. 2005 Dec;13(4):382-95
pubmed: 16304234
World J Pediatr Congenit Heart Surg. 2018 Jan;9(1):60-67
pubmed: 29310561
PLoS One. 2015 May 06;10(5):e0124835
pubmed: 25946026
Am J Respir Crit Care Med. 2011 Dec 1;184(11):1261-9
pubmed: 21868501