ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition.

Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
14 Aug 2020
Historique:
entrez: 21 8 2020
pubmed: 21 8 2020
medline: 21 8 2020
Statut: epublish

Résumé

COVID-19 severity has varied widely, with demographic and cardio-metabolic factors increasing risk of severe reactions to SARS-CoV-2 infection, but the underlying mechanisms for this remain uncertain. We investigated phenotypic and genetic factors associated with subcutaneous adipose tissue expression of Angiotensin I Converting Enzyme 2 (

Identifiants

DOI: 10.1101/2020.08.11.20171108 PMID: 32817962 PMC: PMC7430606
pubmed: 32817962
doi: 10.1101/2020.08.11.20171108
pmc: PMC7430606
pii:
doi:

Types de publication

Preprint

Langues

eng

Commentaires et corrections

Type : UpdateIn

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Auteurs

Julia S El-Sayed Moustafa (JS)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

Anne U Jackson (AU)

Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Sarah M Brotman (SM)

Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.

Li Guan (L)

Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.

Sergio Villicaña (S)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

Amy L Roberts (AL)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

Antonino Zito (A)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Department of Genetics, Harvard Medical School, Boston, MA 02115; USA.

Lori Bonnycastle (L)

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Michael R Erdos (MR)

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Narisu Narisu (N)

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Heather M Stringham (HM)

Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Ryan Welch (R)

Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Tingfen Yan (T)

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Timo Lakka (T)

Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio, Finland.
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland.

Stephen Parker (S)

Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.

Jaakko Tuomilehto (J)

Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Department of Public Health, University of Helsinki, Helsinki, Finland.
Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.

Francis S Collins (FS)

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Päivi Pajukanta (P)

Department of Human Genetics and Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Michael Boehnke (M)

Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Heikki A Koistinen (HA)

Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
University of Helsinki and Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
Minerva Foundation Institute for Medical Research, Helsinki, Finland.

Markku Laakso (M)

Department of Medicine, University of Eastern Finland, Kuopio, Finland.
Kuopio University Hospital, Kuopio, Finland.

Mario Falchi (M)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

Jordana T Bell (JT)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

Laura J Scott (LJ)

Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Karen L Mohlke (KL)

Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.

Kerrin S Small (KS)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

Classifications MeSH