Changes in melatonin receptor expression in a murine model of glaucoma.
Animals
Aqueous Humor
/ drug effects
Disease Models, Animal
Gene Expression Regulation
Glaucoma
/ genetics
Humans
Intraocular Pressure
/ drug effects
Melatonin
/ pharmacology
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Nerve Tissue Proteins
/ genetics
Prazosin
/ pharmacology
Receptor, Melatonin, MT1
/ antagonists & inhibitors
Receptor, Melatonin, MT2
/ antagonists & inhibitors
Receptors, G-Protein-Coupled
/ genetics
Receptors, Melatonin
/ antagonists & inhibitors
Species Specificity
Tetrahydronaphthalenes
/ pharmacology
Tryptamines
/ pharmacology
Journal
Molecular vision
ISSN: 1090-0535
Titre abrégé: Mol Vis
Pays: United States
ID NLM: 9605351
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
11
2019
accepted:
27
07
2020
entrez:
21
8
2020
pubmed:
21
8
2020
medline:
3
7
2021
Statut:
epublish
Résumé
The objective of this study was to evaluate the changes in the melatoninergic receptors of DBA/2J and C57BL/6J mice with the development of glaucoma. DBA/2J mice are widely used to study the physiopathology of glaucoma due to the similarities of their eyes to human eyes and the resulting similarity in the development of their pathology. In addition, melatoninergic receptors are known for their control of intraocular pressure (IOP), reducing the production of aqueous humor; however, little is known about their relationship with the development of this pathology. mRNA expression of MT All melatoninergic receptor expression decayed with the development of the glaucomatous pathology in the DBA/2J mice, and was especially visible for the MT Melatonin receptor expression decays with the development of the glaucomatous pathology. This implies that the physiologic hypotensive effect of endogenous melatonin reducing IOP is not possible. A solution for such changes in receptor expression is the exogenous application of melatonin or any of its analogs that permit the activation of the remaining melatonin receptors.
Substances chimiques
4-phenyl-2-propionamidotetraline
0
5-methoxycarbonylamino-N-acetyltryptamine
0
Gpr50 receptor, mouse
0
Nerve Tissue Proteins
0
Receptor, Melatonin, MT1
0
Receptor, Melatonin, MT2
0
Receptors, G-Protein-Coupled
0
Receptors, Melatonin
0
Tetrahydronaphthalenes
0
Tryptamines
0
luzindole
117946-91-5
Melatonin
JL5DK93RCL
Prazosin
XM03YJ541D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
530-539Informations de copyright
Copyright © 2020 Molecular Vision.
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