Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β

Animals Binding Sites Cattle Cell Line GTP-Binding Protein alpha Subunits, Gs / chemistry Guanosine Diphosphate / metabolism Guanosine Triphosphate / metabolism Isoproterenol / metabolism Models, Molecular Protein Binding Protein Domains Protein Structure, Secondary Receptors, Adrenergic, beta-1 / chemistry
G-protein G-protein-coupled receptor activation of G-proteins cardiac disease cryo-electron microscopy signal transduction structural biology β1-adrenergic receptor

Journal

Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571

Informations de publication

Date de publication:
01 10 2020
Historique:
received: 18 11 2019
revised: 09 02 2020
accepted: 31 07 2020
pubmed: 21 8 2020
medline: 21 10 2020
entrez: 21 8 2020
Statut: ppublish

Résumé

Cardiac disease remains the leading cause of morbidity and mortality worldwide. The β

Identifiants

DOI: 10.1016/j.molcel.2020.08.001 PMID: 32818430 PMC: PMC7541785
pubmed: 32818430
pii: S1097-2765(20)30544-X
doi: 10.1016/j.molcel.2020.08.001
pmc: PMC7541785
mid: NIHMS1619067
pii:
doi:

Substances chimiques

Receptors, Adrenergic, beta-1 0
Guanosine Diphosphate 146-91-8
Guanosine Triphosphate 86-01-1
GTP-Binding Protein alpha Subunits, Gs EC 3.6.5.1
Isoproterenol L628TT009W

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

59-71.e4

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM124152
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103310
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM138676
Pays : United States
Organisme : NCRR NIH HHS
ID : P41 RR001209
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM132307
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA042298
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130478
Pays : United States
Organisme : NCI NIH HHS
ID : F31 CA243235
Pays : United States
Organisme : CIHR
ID : 159464
Pays : Canada

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Références

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Auteurs

Minfei Su (M)

Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.

Lan Zhu (L)

School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.

Yixiao Zhang (Y)

Laboratory of Molecular Electron Microscopy, The Rockefeller University, New York, NY 10065, USA.

Navid Paknejad (N)

Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Raja Dey (R)

Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.

Jianyun Huang (J)

Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.

Ming-Yue Lee (MY)

School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.

Dewight Williams (D)

John M. Cowley Center for High Resolution Electron Microscopy, Arizona State University, Tempe, AZ 85287, USA.

Kelsey D Jordan (KD)

Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY 10027, USA.

Edward T Eng (ET)

Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY 10027, USA.

Oliver P Ernst (OP)

Department of Biochemistry and Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

Joel R Meyerson (JR)

Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.

Richard K Hite (RK)

Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Thomas Walz (T)

Laboratory of Molecular Electron Microscopy, The Rockefeller University, New York, NY 10065, USA.

Wei Liu (W)

School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA. Electronic address: w.liu@asu.edu.

Xin-Yun Huang (XY)

Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA. Electronic address: xyhuang@med.cornell.edu.

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Classifications MeSH

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questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Structural Basis of the Activation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Structural Basis of the Activation of...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Structural Basis of the Activation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines G hétérotrimériques › Sous-unités alpha des protéines G › Sous-unités alpha Gs des protéines G › Structural Basis of the Activation of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides guanyliques › Guanosine diphosphate › Structural Basis of the Activation of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides guanyliques › Guanosine triphosphate › Structural Basis of the Activation of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Isoprénaline › Structural Basis of the Activation of...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Structural Basis of the Activation of...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Structural Basis of the Activation of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › Structural Basis of the Activation of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Structural Basis of the Activation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs adrénergiques › Récepteurs bêta-adrénergiques › Récepteurs bêta-1 adrénergiques › Structural Basis of the Activation of...