Engineering the Plant Secretory Pathway for the Production of Next-Generation Pharmaceuticals.

Humans Molecular Farming / trends Plant Proteins / biosynthesis Plants / chemistry Plants, Genetically Modified / genetics Protein Engineering / trends Recombinant Proteins / biosynthesis Secretory Pathway / genetics
biologics chaperones cleavage folding glycosylation proteases

Journal

Trends in biotechnology
ISSN: 1879-3096
Titre abrégé: Trends Biotechnol
Pays: England
ID NLM: 8310903

Informations de publication

Date de publication:
09 2020
Historique:
received: 10 01 2020
revised: 06 03 2020
accepted: 06 03 2020
entrez: 21 8 2020
pubmed: 21 8 2020
medline: 20 7 2021
Statut: ppublish

Résumé

Production of biologics in plants, or plant molecular pharming, is a promising protein expression technology that is receiving increasing attention from the pharmaceutical industry. Previously, low expression yields of recombinant proteins and the realization that certain post-translational modifications (PTMs) may not occur optimally limited the widespread acceptance of the technology. However, molecular engineering of the plant secretory pathway is now enabling the production of increasingly complex biomolecules using tailored protein-specific approaches to ensure their maturation. These involve the elimination of undesired processing events, and the introduction of heterologous biosynthetic machinery to support the production of specific target proteins. Here, we discuss recent advances in the production of pharmaceutical proteins in plants, which leverage the unique advantages of the technology.

Identifiants

DOI: 10.1016/j.tibtech.2020.03.004 PMID: 32818443
pubmed: 32818443
pii: S0167-7799(20)30064-0
doi: 10.1016/j.tibtech.2020.03.004
pii:
doi:

Substances chimiques

Plant Proteins 0
Recombinant Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1034-1044

Subventions

Organisme : Austrian Science Fund FWF
ID : P 31920
Pays : Austria

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Emmanuel A Margolin (EA)

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Wellcome Trust Centre for Infectious Disease Research in Africa, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa. Electronic address: Emmanuelemmanuel.margolin@uct.ac.za.

Richard Strasser (R)

Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.

Ros Chapman (R)

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Anna-Lise Williamson (AL)

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Wellcome Trust Centre for Infectious Disease Research in Africa, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Edward P Rybicki (EP)

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

Ann E Meyers (AE)

Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Engineering the Plant Secretory Pathway for...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Moléculture › Engineering the Plant Secretory Pathway for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Engineering the Plant Secretory Pathway for...
questionsmedicales.fr › Eucaryotes › Plantes › Engineering the Plant Secretory Pathway for...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Végétaux génétiquement modifiés › Engineering the Plant Secretory Pathway for...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Ingénierie des protéines › Engineering the Plant Secretory Pathway for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Engineering the Plant Secretory Pathway for...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Exocytose › Voie de sécrétion › Engineering the Plant Secretory Pathway for...