Concussion increases CA1 activity during prolonged inactivity in a familiar environment.
Blast
CNMF-E
GCamp6f
Home cage
Miniscope
Novel
Open field
TBI
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
14
04
2020
revised:
02
08
2020
accepted:
12
08
2020
pubmed:
21
8
2020
medline:
11
3
2021
entrez:
21
8
2020
Statut:
ppublish
Résumé
Although hippocampal damage plays a key role in impairments after concussion, differences in hippocampal information processing during recovery are unknown. Micro-endoscopic calcium imaging was performed before and after primary blast injury in freely behaving mice in two environments: their familiar home cage and a novel open field. Results show that after concussion CA1 activity increased in the familiar environment in which animals were awake and mostly immobile but was unaltered in a novel environment which the animals actively and constantly explored. As awake immobility parallels cognitive rest, a common treatment for patients, the results imply that prolonged cognitive rest may unwittingly impede concussion recovery.
Identifiants
pubmed: 32818488
pii: S0014-4886(20)30266-1
doi: 10.1016/j.expneurol.2020.113435
pmc: PMC7830810
mid: NIHMS1662510
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113435Subventions
Organisme : NINDS NIH HHS
ID : R01 NS088176
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Annu Rev Biophys. 2017 May 22;46:271-293
pubmed: 28301770
Transl Stroke Res. 2011 Dec;2(4):546-55
pubmed: 23227133
Neuroscience. 2005;133(1):1-15
pubmed: 15893627
Exp Neurol. 2016 Sep;283(Pt A):16-28
pubmed: 27246999
Oncotarget. 2018 Jan 4;9(14):11515-11527
pubmed: 29545916
J Athl Train. 2017 Mar;52(3):262-287
pubmed: 28387547
Front Cell Neurosci. 2014 Dec 19;8:435
pubmed: 25565968
Hippocampus. 2015 Oct;25(10):1073-188
pubmed: 26135716
Curr Neurol Neurosci Rep. 2017 Jul;17(7):52
pubmed: 28500417
Hippocampus. 2001;11(5):551-68
pubmed: 11732708
Front Behav Neurosci. 2014 Oct 08;8:349
pubmed: 25339878
Phys Med Rehabil Clin N Am. 2016 May;27(2):373-93
pubmed: 27154851
Nat Neurosci. 2010 Nov;13(11):1433-40
pubmed: 20890294
J Biomech Eng. 2014 Feb;136(2):021008
pubmed: 24384610
Elife. 2018 Feb 22;7:
pubmed: 29469809